Fig. 6

Expression heatmaps and gene ontologies associated with the most connected hub genes in the turquoise module based on their protein-protein interactome. The genes and their connectivity in the protein-protein interaction network is shown in Fig. 5. Genes in the Sub Cluster 1 were associated with mitochondrial protein translation, and the genes in the Sub Cluster 2 were enriched in mitochondrial energy metabolism associated GO terms. Gene ontology analysis was carried out using the ClueGo application in Cytoscape (p-adj <0.05). All selected genes showed a clear downregulation in mdm muscles, where psoas showed the most significant response. The column names at the bottom of the heat maps identifies the sample replicates; E-EDL, P-psoas, and S-soleus, followed by the replicate number