Fig. 4

Results returned from co-expression network and cross-species expression conservation analyses. A A heat map showing relationships between modules and sample groups. The correlation and significance within a cell measures the degree of relationships between the corresponding module and sample group. B A gene dendrogram of clustered modules. C A network representing a gene module. Sizes of nodes correspond to degrees of connectivity (number of connections). The largest nodes tend to be hub genes. D Violin graphs showing distribution of correlation coefficient of ortholog gene expression profiles across sample groups. E Molecular phylogenetic tree of ortholog genes and their expression profile comparison across four tissues. F Scatter plot of gene expression ratios of 4695 pairs of 1:1 orthologs (horse-pig) in brain vs. muscle. Up- or downregulation of a gene in horse brain is highly predictive of up- or downregulation of its pig ortholog in brain