Table 2 Pathways of candidate lncRNAs target mRNAs with the largest significant difference in KEGG analysis
Pathway | Fisher-P value | Top enriched genes |
|---|---|---|
Wnt signaling pathway | 0.000210417 | BTRC,CAMK2B,CAMK2D,CCND3,CHD8,CREBBP,CSNK2B,CTBP1,CTBP2,CTNNB1,CTNNBIP1,DAAM1,FBXW11,FRAT1,FZD8,FZD9,GSK3B,LEF1,MAPK8,MYC |
Pathways in cancer | 0.00089539 | AGTR1B,ARHGEF1,ARNT,ARNT2,BAK1,BAX,BCL2,BCL2L11,BIRC7,BMP4,BRCA2,CALM4,CAMK2B,CAMK2D,CASP8,CASP9,CCDC6,CCNA1,CCND3,CDKN1A |
Thyroid cancer | 0.00277648 | BAK1,BAX,CCDC6,CDKN1A,CTNNB1,GADD45A,GADD45B,HRAS,LEF1,MYC,RET,TCF7,TCF7L1,TPR,TRP53 |
Basal cell carcinoma | 0.003190856 | BAK1,BAX,BMP4,CDKN1A,CTNNB1,FZD8,FZD9,GADD45A,GADD45B,GLI2,GLI3,GSK3B,LEF1,TCF7,TCF7L1,TRP53,WNT10A,WNT11,WNT5A,WNT5B |
Endometrial cancer | 0.005658717 | BAK1,BAX,CASP9,CDKN1A,CTNNB1,ELK1,GADD45A,GADD45B,GSK3B,HRAS,LEF1,MLH1,MYC,PIK3R2,PIK3R3,PTEN,SOS2,TCF7,TCF7L1,TRP53 |
MAPK signaling pathway | 0.007583797 | ARRB2,BDNF,CACNA1A,CACNA1F,CACNA1S,CACNA2D1,CACNB3,CACNB4,CACNG1,CDC25B,CHUK,CSF1R,DUSP10,DUSP2,DUSP4,DUSP6,DUSP8,ELK1,EPHA2,FGF2 |
Phosphatidylinositol signaling system | 0.008641106 | CALM4,CDS2,DGKG,DGKQ,INPP4A,INPP5A,INPP5E,INPPL1,IP6K3,IPMK,ITPKA,MTMR14,MTMR2,OCRL,PI4K2A,PI4KB,PIK3C3,PIK3R2,PIK3R3,PIKFYVE |
Glutamatergic synapse | 0.00926066 | CACNA1A,DLG4,DLGAP1,GNAO1,GNAQ,GNAS,GNB3,GNB4,GNB5,GNG10,GNG11,GNG4,GNG8,GRIA4,GRIN1,GRM1,GRM7,GRM8,HOMER2,KCNJ3 |
Breast cancer | 0.009525387 | BAK1,BAX,BRCA2,CDKN1A,CTNNB1,E2F1,E2F3,FGF2,FGF22,FGF23,FGF6,FGF9,FRAT1,FZD8,FZD9,GADD45A,GADD45B,GSK3B,HRAS,IGF1 |
Gastric cancer | 0.01354918 | ABCB1A,BAK1,BAX,BCL2,CDH17,CDKN1A,CTNNB1,E2F1,E2F3,FGF2,FGF22,FGF23,FGF6,FGF9,FGFR2,FRAT1,FZD8,FZD9,GADD45A,GADD45B |