Table 3 Participant characteristics for the training data (MEC) and the three validation datasets (CENIC, HSS, and METS)
From: Predicting nicotine metabolism across ancestries using genotypes
| Â | MEC | CENIC | HSS | METS |
|---|---|---|---|---|
| Â | (N=2239) | (N=515) | (N=580) | (N=315) |
Age | ||||
 Mean (SD) | 63.9 (7.19) | 43.4 (13.2) | 60.6 (9.40) | 33.8 (10.9) |
 Median [Min, Max] | 63.0 [45.0, 86.0] | 44.0 [18.0, 75.0] | 60.6 [19.6, 83.2] | 30.0 [18.0, 69.0] |
Body Mass Index | ||||
 Mean (SD) | 26.3 (5.31) | 30.0 (6.70) | 27.1 (6.10) | 25.6 (4.75) |
 Median [Min, Max] | 25.6 [11.3, 62.8] | 29.2 [15.2, 56.0] | 26.1 [14.4, 54.8] | 24.9 [15.9, 49.1] |
 Missing | 0 (0%) | 3.00 (0.5%) | 0 (0%) | 0 (0%) |
Gender | ||||
 Male | 1040 (46.4%) | 306 (59.4%) | 284 (49.0%) | 141 (44.8%) |
 Female | 1199 (53.6%) | 209 (40.6%) | 296 (51.0%) | 174 (55.2%) |
Current Smoker | ||||
 Yes | 2239 (100%) | 515 (100%) | 580 (100%) | 120 (38.1%) |
 No | 0 (0%) | 0 (0%) | 0 (0%) | 195 (61.9%) |
Self Reported Race | ||||
 African American | 364 (16.3%) | 107 (20.8%) | 0 (0%) | 49 (15.6%) |
 American Indian/Alaskan Native | 0 (0%) | 5 (1.0%) | 0 (0%) | 0 (0%) |
 Asian American | 0 (0%) | 6 (1.2%) | 0 (0%) | 51 (16.2%) |
 Multirace | 0 (0%) | 25 (4.9%) | 0 (0%) | 0 (0%) |
 White | 437 (19.5%) | 372 (72.2%) | 197 (34.0%) | 215 (68.3%) |
 Japanese American | 674 (30.1%) | 0 (0%) | 191 (32.9%) | 0 (0%) |
 Native Hawaiian/Pacific Islander | 311 (13.9%) | 0 (0%) | 192 (33.1%) | 0 (0%) |
 Latino | 453 (20.2%) | 0 (0%) | 0 (0%) | 0 (0%) |
Natural log Nicotine Metabolite Ratio | ||||
 Mean (SD) | 1.11 (0.898) | 1.50 (0.720) | -0.324 (0.959) | -1.58 (0.548) |
 Median [Min, Max] | 1.20 [-3.91, 3.60] | 1.54 [-2.54, 3.35] | -0.267 [-3.30, 2.90] | -1.57 [-3.22, -0.240] |