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Table 2 Replication of previous GWAS associations from Tian et al. report

From: Genome-wide association analyses of common infections in a large practice-based biobank

Phenotype

Cytoband

Gene_context

From Tian et al. report

From BioVU replication

Variants

OR/ effectb

95%CI

SNP in BioVU

N

Effect allele

Other allele

EAF

OR

95% CI

P

Herpes zoster

6p21.33

HLA

rs2523591

1.14

(1.13–1.16)

rs2523591

8261

G

A

0.59

1.01

(0.90–1.12)

0.88

9p21.3

IFNA21

rs7047299

1.07

(1.06–1.09)

rs7047299

8261

A

G

0.56

1.18

(1.06–1.32)

0.0026#

Herpes labialis

6p21.33

HLA

rs885950

1.08

(1.07–1.09)

rs885950

3916

C

A

0.45

0.99

(0.85–1.16)

0.91#

Infectious mononucleosis

6p21.33

HLA

rs2596465

1.08

(1.06–1.09)

rs2596465

1276

T

C

0.45

1.17

(0.89–1.54)

0.26#

Hepatitis B

6p21.32

HLA

rs9268652

1.32

(1.25–1.38)

rs9268652

2453

G

A

0.76

1.01

(0.81–1.28)

0.9

Tuberculosis or a positive TB test

6p21.32

HLA

rs2894257

1.36

(1.33–1.39)

-

-

-

-

-

-

-

-

Streptococcal pharyngitis*

6p21.33

HLA

rs1055821

0.08

(0.06–0.09)

-

-

-

-

-

-

-

-

1p36.23

ERRFI1–-[]–-SLC45A1

rs35395352

0.03

(0.03–0.04)

rs7548511

10,967

A

G

0.7

1.02

(0.92–1.13)

0.73

Pneumonia

6p21.33

HLA

rs3131623

1.1

(1.09 − 1.12)

rs3131623

38,310

T

A

0.84

1.01

(0.96–1.07)

0.67

Candidiasis*

18q12.1

DSG1

rs200520431

0.11

(0.09 − 0.12)

-

-

-

-

-

-

-

-

14q23.1

PRKCH

rs2251260

0.05

(0.04 − 0.06)

rs2251260

13,212

T

C

0.19

0.99

(0.90–1.08)

0.82

14q32.2

[]–-C14orf177

rs7161578

0.04

(0.03 − 0.04)

rs7161578

13,212

T

C

0.39

0.98

(0.91–1.05)

0.5

UTI*

8q24.3

JRK-[]-PSCA

rs2976388

0.04

(0.04 − 0.05)

rs2976388

56,154

G

A

0.57

1.02

(0.98–1.05)

0.32

15q15.3

FRMD5

rs146906133

0.38

(0.32 − 0.45)

-

-

-

-

-

-

-

-

Otitis media

19q13.33

FUT2

rs681343

1.11

(1.1–1.12)

rs681343

14,604

C

T

0.51

1.05

(0.98–1.12)

0.14

22q11.21

TBX1

rs1978060

1.09

(1.08–1.1)

rs1978060

14,604

G

A

0.59

1.03

(0.96–1.10)

0.45

10p12.1

RAB18–[]–MKX

rs2808290

1.07

(1.07–1.08)

rs2808290

14,604

C

T

0.51

1.09

(1.02–1.16)

0.0096

15q26.2

SPATA8–-[]–-LINC00923

rs7174062

1.08

(1.07–1.09)

rs7174062

14,604

G

A

0.73

1.03

(0.96–1.11)

0.38

6p21.32

HLA

rs4329147

1.11

(1.09–1.13)

rs9270656

14,604

A

C

0.85

1.08

(0.99–1.18)

0.07

9q34.2

ABO

rs8176643

1.06

(1.05–1.07)

rs600038

14,604

C

T

0.21

1.02

(0.94–1.10)

0.64#

2p16.1

EFEMP1

rs1802575

1.09

(1.07–1.1)

rs1802575

14,604

G

C

0.87

0.13

(0.89–1.08)

0.72#

2p24.1

NT5C1B-RDH14–-[]–-OSR1

rs5829676

1.06

(1.05–1.07)

rs11694107

14,604

A

G

0.4

1.05

(0.98–1.12)

0.16#

11q13.3

FGF3–-[]–ANO1

rs72931768

1.09

(1.07–1.1)

rs72931768

14,604

G

C

0.89

0.11

(0.91–1.10)

0.99#

7q11.22

AUTS2

rs35213789

1.06

(1.05–1.07)

rs35213789

14,604

C

T

0.74

0.26

(0.97–1.11)

0.31#

7q22.3

CDHR3

rs114947103

1.07

(1.06–1.08)

rs114947103

14,604

C

T

0.18

1.09

(1.00–1.18)

0.0407#

8q22.2

NIPAL2–[]–KCNS2

rs13281988

1.06

(1.05–1.07)

rs13281988

14,604

C

G

0.3

1.05

(0.98–1.12)

0.2#

3p21.31

BSN

rs67035515

1.07

(1.05–1.08)

-

-

-

-

-

-

-

-

6q26

PLG

rs73015965

1.43

(1.34–1.53)

rs73027818

14,604

T

C

0.01

1.44

(0.89–2.33)

0.14

  1. *For streptococcal pharyngitis, candidiasis and UTI, Tian et al. used frequency of those infections as quantitative traits, while we identified cases/controls and used them as binary traits
  2. #In the post-analysis power calculation there was less than 50% power to detect the odds ratios reported by Tian et al. [11]
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