Fig. 3
From: Leveraging family history in genetic association analyses of binary traits
Manhattan Plots of T2D association analysis based on FHS data results using a CC-GWAS, b LT-FH, and c Fam-meta. For each method, the x-axis represents chromosome positions of tested variants across the genome, while the y-axis represents -log10 P-values for the association of genetic variants with T2D. The horizontal dashed red line in each figure represents the threshold for genome-wide significance, which corresponds to P = 5 × 10–8. All variants that passed the threshold are labelled with their corresponding gene names or closest reference gene names