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Table 1 Power of CC-GWAS, LT-FH and Fam-meta using the simulation parameters of model 2: we used a proportion of phenotypic variance explained by SNPs at 1% each; trait heritability was 0.28, while age and sex each explained 10% and 5% of the total variance, respectively. The sample size was 1800, consisting of 400 simple nuclear families. We ran a total of 5000 simulations under H1

From: Leveraging family history in genetic association analyses of binary traits

Causal SNP minor allele frequency

CC-GWAS

LT-FH

Fam-meta

Power

Increase from CC-GWAS

Power

Increase from CC-GWAS

0.01

0.742

0.770

0.028

0.786

0.044

0.02

0.718

0.757

0.039

0.774

0.056

0.05

0.696

0.750

0.054

0.767

0.071

0.10

0.667

0.732

0.065

0.750

0.083

0.20

0.656

0.716

0.060

0.737

0.081

0.30

0.658

0.714

0.056

0.739

0.081

0.40

0.639

0.707

0.068

0.729

0.090

0.50

0.620

0.689

0.069

0.707

0.087