Leveraging family history in genetic association analyses of binary traits

BMC Genomics

Table 2 Power of CC-GWAS, LT-FH and Fam-meta under model 3 scenario with an interaction between age and genotype of causal variants. We ran a total of 5000 simulations

Causal SNP minor allele frequency	CC-GWAS	LT-FH		Fam-meta
Causal SNP minor allele frequency	CC-GWAS	Power	Increase from CC-GWAS	Power	Increase from CC-GWAS
0.01	0.789	0.841	0.052	0.861	0.072
0.02	0.750	0.832	0.082	0.864	0.114
0.05	0.732	0.838	0.106	0.859	0.127
0.10	0.718	0.833	0.115	0.854	0.136
0.20	0.695	0.822	0.127	0.850	0.155
0.30	0.686	0.814	0.128	0.846	0.160
0.40	0.684	0.819	0.135	0.842	0.158
0.50	0.660	0.806	0.146	0.831	0.171

ISSN: 1471-2164