From: Leveraging family history in genetic association analyses of binary traits
Causal SNP minor allele frequency | Fam-meta | Increase in power from CC-GWAS to Fam-meta | ||
---|---|---|---|---|
Two grandparents | Four grandparents | Two grandparents | Four grandparents | |
0.01 | 0.689 | 0.699 | 0.011 | 0.021 |
0.02 | 0.672 | 0.680 | 0.013 | 0.020 |
0.05 | 0.629 | 0.655 | 0.015 | 0.041 |
0.10 | 0.610 | 0.633 | 0.022 | 0.045 |
0.20 | 0.601 | 0.625 | 0.025 | 0.049 |
0.30 | 0.588 | 0.609 | 0.032 | 0.053 |
0.40 | 0.571 | 0.596 | 0.021 | 0.045 |
0.50 | 0.562 | 0.590 | 0.021 | 0.050 |