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Table 3 Power of CC-GWAS and Fam-meta evaluated using more distant relatives’ information. Grandparents’ phenotypic status was used instead of parents’ phenotypic status for Fam-meta. We compared the power of Fam-meta when including two grandparents vs. four grandparents. LT-FH could not leverage second-degree relatives and thus results are not presented in this table

From: Leveraging family history in genetic association analyses of binary traits

Causal SNP minor allele frequency

Fam-meta

Increase in power from CC-GWAS to Fam-meta

Two grandparents

Four grandparents

Two grandparents

Four grandparents

0.01

0.689

0.699

0.011

0.021

0.02

0.672

0.680

0.013

0.020

0.05

0.629

0.655

0.015

0.041

0.10

0.610

0.633

0.022

0.045

0.20

0.601

0.625

0.025

0.049

0.30

0.588

0.609

0.032

0.053

0.40

0.571

0.596

0.021

0.045

0.50

0.562

0.590

0.021

0.050