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Table 4 Main T2D associations from application to FHS data ordered by CC-GWAS P-value. The first four genetic loci have P-values less than the genome-wide significant threshold of P = 5 × 10–8 with at least one method, and the other two loci have been previously reported in literature to be associated with T2D and have P-values less than a suggestive threshold of P = 10–3 with at least one method

From: Leveraging family history in genetic association analyses of binary traits

 

CC-GWAS

LT-FH

Fam-meta

rsIDs (Chr:b37Pos Mb)

Effect Allele and Frequency

Closest Gene Label

t-statistic

P-value

t-statistic

P-value

Tmeta

P-value

rs7903146

(10:114.8)

T (0.31)

TCF7L2

6.69

2.3 × 10–11

7.04

2.0 × 10–12

6.92

4.5 × 10–12

rs78825768 (5:178.7)

C (0.048)

ADAMTS2

5.70

1.2 × 10–8

4.53

6.0 × 10–6

5.72

1.1 × 10–8

rs150003225

(5:119.7)

C (0.012)

PRR16

5.69

1.3 × 10–8

5.02

5.1 × 10–7

5.53

3.2 × 10–8

rs78855997

(13:94.2)

G (0.010)

GPC6

5.51

3.5 × 10–8

4.20

2.6 × 10–5

5.23

1.7 × 10–7

rs2383208

(9:22.1)

G (0.18)

CDKN2B-AS1

-4.15

3.4 × 10–5

-4.50

6.8 × 10–6

-4.18

2.9 × 10–5

rs10830963

(11:92.7)

G (0.27)

MTNR1B

3.84

1.2 × 10–4

2.53

1.1 × 10–2

3.68

2.4 × 10–4