Fig. 3

The enriched KEGG pathway of DEGs and PPI network analysis in JEG-3, U-251 MG, HK-2 cell lines. a The enriched KEGG pathway of DEGs in JEG-3, U-251 MG, and HK-2 cells. Here, the total top 30 significant pathways ranked by adjusted p-value in 3 cell lines were displayed. b The example enriched KEGG pathway of DEGs in U-251 MG cells. c The example enriched KEGG pathway of DEGs in HK-2 cells. Here, the lines represent the interactions in the PPI network. Node colors represent DEGs annotated on different pathways. DEGs on JEG-3 cells sporadically map to the PPI network, so their PPI network is not shown. Enrichment analyses were performed by clusterProfiler package of R software. Hypergeometric tests were used to screen enriched KEGG pathways, and P-values were further adjusted by the default “Holm” method. Those KEGG pathways with an adjusted P-value < 0.05 were considered significant