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Fig. 3 | BMC Genomics

Fig. 3

From: Association of mTORC1‑dependent circulating protein levels with cataract formation: a mendelian randomization study

Fig. 3

SNPs influence the causal-effect with MR estimate. (Each dots represents the causal effect on the result of each IV, and each region corresponds to a different mTORC1 downstream protein, including RP-S6K, EIF4EBP, EIF-4G, EIF-4E, and EIF-4A. The outer annular layer represents the P-value of MR, “P-value of MR” represent the P-value of the corresponding “beta value of each SNP”. The inner layer is the beta value of each SNP, beta coefficients are shown as per 1 standard deviation increase in the trait, and β = log(or). The gray dotted line between inner layer means beta equals zero. SNP, single nucleotide polymorphism; RP-S6K, ribosomal protein S6K kinase; EIF4EBP, eukaryotic initiation factor 4E-binding protein; EIF-4G, translation initiation factor 4G; EIF-4E, translation initiation factor 4E; EIF-4A, translation initiation factor 4A; MR, Mendelian randomization.)

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