Table 1 Mendelian Randomization (MR) estimate for the association between mTORC1/RP-S6K, mTORC1/EIF4EBP pathway, and cataract
Exposure | Method | OR (95% CI) | P-value |
|---|---|---|---|
RP-S6K | IVW | 1.04(1,01-1.08) | 0.021 |
WM | 1.04(0.99–1.09) | 0.103 | |
MR Egger | 1.00(0.94–1.07) | 0.974 | |
MR. RAPS | 1.03(1.01–1.04) | 0.113 | |
EIF4EBP | IVW | 1.09(1.03–1.16) | 0.004 |
WM | 1.09(1.00-1.18) | 0.038 | |
MR Egger | 1.06(0.93–1.22) | 0.391 | |
MR. RAPS | 1.08(1.05–1.11) | 0.007 | |
EIF-4G | IVW | 1.02(0.94–1.10) | 0.643 |
WM | 1.02(0.94–1.13) | 0.548 | |
MR Egger | 1.07(0.88–1.29) | 0.541 | |
MR. RAPS | 1.04(1.00-1.08) | 0.333 | |
EIF-4E | IVW | 1.03(0.97–1.09) | 0.308 |
WM | 1.05(0.99–1.11) | 0.107 | |
MR Egger | 1.01(0.90–1.15) | 0.816 | |
MR. RAPS | 1.04(1.02–1.06) | 0.066 | |
EIF-4A | IVW | 1.03(0.98–1.07) | 0.338 |
WM | 1.03(0.97–1.08) | 0.315 | |
MR Egger | 1.03(0.95–1.12) | 0.506 | |
MR. RAPS | 1.02(1.00-1.05) | 0.291 |