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Fig. 5 | BMC Genomics

Fig. 5

From: Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions

Fig. 5

Early Response to Activin and BMP4/7 Reveals Unexpected Overlap. A Number of differentially expressed genes between successive developmental stages of the endoderm and ventral mesoderm lineage, padj ≤ 0.05. B Venn Diagrams for the total number of DE genes between stages for the epidermal and neural lineages, as well as the number of genes increasing and decreasing over time. C-F Heatmaps of the top 50 genes differentially increased in response to (C) BMP4/7 at stage 10 and/or 10.5 (D) BMP4/7 at stage 11 and/or 12. (E) Activin at stage 10 and/or 10.5 (F) Activin at stage 11 and/or 12. All genes in heatmaps are ranked by Log2FC of differential expression of either mesoderm (BMP4/7) or endoderm (Activin) compared to the wildtype epidermal lineage. Only genes increasing in response to BMP4/7 or Activin with a minimum expression of 10TPM at the relevant stages and higher expression at the relevant stage than at stage 9 were included in the heatmap. Colors represent z-scores of TPM

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