Fig. 5

Enrichment gene ontology analysis and MCODE networks based on the protein-protein interaction (PPI) enrichment analysis. a,c,e Top 20 enriched terms identified based on the individual gene lists correspondent to significant proteins affected by age, hydration status or interaction, respectively. b,d,f PPI clusters identified by MCODE for individual gene lists based on the significant proteins identified by age, hydration status or interaction effects, respectively. Pathway and process enrichment analysis was applied to each MCODE cluster independently, and the three best-scoring terms by p-value are retained as the functional description of the corresponding clusters, shown in the tables adjacent to corresponding network plots. Nodes represent proteins, and edges represent the interaction between those proteins. Figures were obtained from enrichment and MCODE PPI analyses using Metascape