Evolutionary genetics of flipper forelimb and hindlimb loss from limb development-related genes in cetaceans

BMC Genomics

Table 1 Two-ratio model estimating ω values in 16 limb-related genes in mammals

Gene	Models	ω0	ωc	2ΔLnL	P-value
BMP2	One-ratio (ω0)	0.0864		3.1540	0.0757
BMP2	Two-ratio (ω0, ωc)	0.0868	0.0001
BMP4	One-ratio (ω0)	0.0701		0.0225	0.8808
BMP4	Two-ratio (ω0, ωc)	0.0700	0.0791
BMP7	One-ratio (ω0)	0.0176		0.7374	0.3905
BMP7	Two-ratio (ω0, ωc)	0.0175	0.0387
FGF8	One-ratio (ω0)	0.0051		0.4907	0.4836
FGF8	Two-ratio (ω0, ωc)	0.0051	0.0001
FGF10	One-ratio (ω0)	0.0628		0.0027	0.9589
FGF10	Two-ratio (ω0, ωc)	0.0628	0.0875
GREM1	One-ratio (ω0)	0.0208		0.7747	0.3789
GREM1	Two-ratio (ω0, ωc)	0.0208	0.0001
HAND2	One-ratio (ω0)	0.0082		0.0004	0.9849
HAND2	Two-ratio (ω0, ωc)	0.0082	0.4476
LMBR1	One-ratio (ω0)	0.0813		0.0300	0.8633
LMBR1	Two-ratio (ω0, ωc)	0.0813	0.1252
HOXA13	One-ratio (ω0)	0.0213		2.5987	0.1069
HOXA13	Two-ratio (ω0, ωc)	0.0214	0.0001
PITX1	One-ratio (ω0)	0.0142		0.8026	0.3703
PITX1	Two-ratio (ω0, ωc)	0.0143	0.0001
PTCH1	One-ratio (ω0)	0.0526		0	0.9961
PTCH1	Two-ratio (ω0, ωc)	0.0526	0.0526
SMO	One-ratio (ω0)	0.0329		0.4960	0.4813
SMO	Two-ratio (ω0, ωc)	0.0329	0.0007
SHH	One-ratio (ω0)	0.0286		0.0514	0.8207
SHH	Two-ratio (ω0, ωc)	0.0286	0.0001
TBX4	One-ratio (ω0)	0.0381		1.5630	0.2112
TBX4	Two-ratio (ω0, ωc)	0.0379	0.1474
TBX5	One-ratio (ω0)	0.0363		7.9501	0.0048
TBX5	Two-ratio (ω0, ωc)	0.0361	7.4672
WNT9A	One-ratio (ω0)	0.0083		0.2138	0.6438
WNT9A	Two-ratio (ω0, ωc)	0.0084	0.0001

ωc is for the common ancestor of Cetacea (the foreground branch). ω0 is for all other branches (the background branches)

ISSN: 1471-2164