Fig. 6

Differentially expressed cell death-related genes in Halichondria panicea. a Heatmap showing differentially expressed genes with predicted functions in regulated cell death, and GO terms associated with cell death (blue), its negative regulation (yellow), or both (pink) (Additional file 6: Supplementary Table 2). b Schematic figure showing selected products of differentially expressed genes mapped onto regulated cell death pathways. Blue, pathway components linked to regulated cell death induction in sponges and/or other animals. Yellow, pathway components linked to regulated cell death inhibition. Pink, pathway components linked to both induction and inhibition of regulated cell death. Grey, pathway components encoded in the H. panicea transcriptome, but not differentially expressed in our study. Dotted lines indicate partial sequences that lack information about specific domains in H. panicea that are found in vertebrate homologs. APAF-1, Apoptotic protease activating factor 1; Bak, Bcl-2 homologous antagonist/killer; BHP, Bcl-2 homologous protein; DAMPs, damage-associated molecular patterns; DEATH, Death fold motif found in some proteins implicated in regulated cell death and inflammation; FADD-like, Fas-associated death domain protein-like; HIG, hypoxia-inducible domain-containing protein; MAMPs, microbe-associated molecular patterns; MAPK, Mitogen-activated protein kinase; NF-κB, Nuclear factor κ-light-chain-enhancer of activated B cells; TNF, Tumour necrosis factor; NLR-like, NOD-like receptor; TNFR, Tumour necrosis factor receptor; TRAFs, Tumor necrosis factor receptor-associated factors