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Fig. 4 | BMC Genomics

Fig. 4

From: Genome-wide differential DNA methylation analysis of MDA-MB-231 breast cancer cells treated with curcumin derivatives, ST08 and ST09

Fig. 4

A Hypermethylation of ANKRD18B promoter by ST09 treatment. B Overall survival of breast cancer patients shown by GEPIA analysis of ANKRD18B.Changes in ST08, ST09-mediated modification of DNA methylation in CpG island correlate with changes in gene expression. We performed genome-wide gene expression analyses to evaluate if ST08, ST09-mediated DNA methylation changes correlated with gene expression variation. Genes that showed reproducible DNA methylation changes after ST08 (C), ST09 (D) treatment (Δβ > 0.1) were matched with genes that showed ≥ 1-fold differences in gene expression. Those genes that showed an inverse correlation between methylation and gene expression changes are encircled in the graph. E Promoter methylation status of genes in normal and tumor breast cancer patient samples using SMART App [34]. F hypomethylation of HOXA10 promoter by ST09 treatment

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BMC Genomics

ISSN: 1471-2164

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