Fig. 4
From: Comparative epigenomics by machine learning approach for neuroblastoma
(A) DNA methylation pattern of MYCN gene (NM_005378) and its neighbor regions at approximately ±100 kb of TSS. Samples were classified as group A, B, C, D1, and D2. From top, annotated genes on refseq (“UCSC_RefGene_Group”), relation to CpG island (“Relation_to_UCSC_CpG_Island”), enhancer annotation (450 K enhancer), classified group by CMSk, and top 10,000 importance probes. Annotated genes, relation to CpG island, and enhancer annotation are followed by EPIC manifest. Colors of “UCSC_RefGene_Group” and “Relation_to_UCSC_CpG_Island” are shown in right panel. Upper left triangle and lower right triangle indicate the isolation pattern of the class. For example, red upper left triangle means high β-value is observed in most of group A sample and not observed in other groups. Details of annotation method of CMSk are described in Materials and Methods. (B) EDAR. (C) FAM13A. (D) PRDM8