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Table 3 Linear regression models for lnSAF in R (GSA)

From: Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes

 

Model 1

Model 2

Model 3

Model 4

Covariate

Beta

SE

P-value

Beta

SE

P-value

Beta

SE

P-value

Beta

SE

P-value

Age

1.5 × 10–02

6.0 × 10–04

 < 2 × 10–16

1.5 × 10–02

6.0 × 10–04

 < 2 × 10–16

1.0 × 10–02

6.2 × 10–04

 < 2 × 10–16

1.0 × 10–02

6.1 × 10–04

 < 2 × 10–16

Age squared

-4.9 × 10–05

6.8 × 10–06

3.0 × 10–13

-4.9 × 10–05

6.8 × 10–06

4.4 × 10–13

-9.2 × 10–06

6.8 × 10–06

1.8 × 10–01

-7.1 × 10–06

6.8 × 10–06

3.0 × 10–01

Male sex

2.5 × 10–02

2.6 × 10–03

 < 2 × 10–16

2.5 × 10–02

2.6 × 10–03

 < 2 × 10–16

6.7 × 10–03

2.6 × 10–03

1.1 × 10–02

9.8 × 10–03

2.6 × 10–03

1.9 × 10–04

Smoking status

  non-smoker

Ref

-

-

Ref

-

-

Ref

-

-

Ref

-

-

  previous smoker

3.9 × 10–02

3.5 × 10–03

 < 2 × 10–16

3.9 × 10–02

3.5 × 10–03

 < 2 × 10–16

2.8 × 10–02

3.4 × 10–03

9.0 × 10–16

2.9 × 10–02

3.4 × 10–03

 < 2 × 10–16

  current smoker

8.3 × 10–02

3.3 × 10–03

 < 2 × 10–16

8.2 × 10–02

3.3 × 10–03

 < 2 × 10–16

6.2 × 10–02

3.3 × 10–03

 < 2 × 10–16

6.4 × 10–02

3.3 × 10–03

 < 2 × 10–16

  BMI

2.7 × 10–03

3.2 × 10–04

 < 2 × 10–16

2.6 × 10–03

3.2 × 10–04

1.0 × 10–15

2.3 × 10–03

3.1 × 10–04

3.7 × 10–13

1.8 × 10–03

3.2 × 10–04

1.4 × 10–08

  eGFR

-4.9 × 10–04

1.1 × 10–04

5.0 × 10–06

-4.9 × 10–04

1.1 × 10–04

7.4 × 10–06

-4.7 × 10–04

1.1 × 10–04

8.3 × 10–06

-5.3 × 10–04

1.1 × 10–04

7.2 × 10–07

  rs1495741 copies G-allele

-3.7 × 10–02

2.8 × 10–03

 < 2 × 10–16

-3.7 × 10–02

2.8 × 10–03

 < 2 × 10–16

-3.7 × 10–02

2.8 × 10–03

 < 2 × 10–16

-3.8 × 10–02

2.8 × 10–03

 < 2 × 10–16

  rs1495741 heterozygosity

-2.4 × 10–02

3.5 × 10–03

2.1 × 10–11

-2.4 × 10–02

3.5 × 10–03

2.2 × 10–11

-2.4 × 10–02

3.4 × 10–03

7.6 × 10–12

-2.4 × 10–02

3.4 × 10–03

7.9 × 10–12

Inclusion method

  Family doctor

Ref

-

-

Ref

-

-

Ref

-

-

Ref

-

-

  Included family members

-7.5 × 10–03

3.1 × 10–03

1.4 × 10–02

-7.6 × 10–03

3.1 × 10–03

1.2 × 10–02

-6.2 × 10–03

3.0 × 10–03

3.8 × 10–02

-6.3 × 10–03

3.0 × 10–03

3.4 × 10–02

  Self-administrated

-1.5 × 10–02

4.0 × 10–03

1.5 × 10–04

-1.5 × 10–02

4.0 × 10–03

1.3 × 10–04

-1.3 × 10–02

3.9 × 10–03

1.2 × 10–03

-1.2 × 10–02

3.9 × 10–03

1.7 × 10–03

  HbA1c

-

-

-

1.6 × 10–03

4.4 × 10–04

3.0 × 10–04

1.5 × 10–03

4.3 × 10–04

3.1 × 10–04

1.5 × 10–03

4.3 × 10–04

5.7 × 10–04

  Coffee drinking status

-

-

-

-

-

-

1.2 × 10–02

4.5 × 10–03

9.2 × 10–03

1.2 × 10–02

4.4 × 10–03

6.0 × 10–03

  cups per day

-

-

-

-

-

-

1.6 × 10–02

7.1 × 10–04

 < 2 × 10–16

1.6 × 10–02

7.1 × 10–04

 < 2 × 10–16

  Reflectance

-

-

-

-

-

-

-

-

-

1.9 × 10–01

1.9 × 10–02

 < 2 × 10–16

  Adjusted R-squared

0.46

0.46

0.48

0.49