Fig. 5From: NSD1 gene evolves under episodic selection within primates and mutations of specific exons in humans cause Sotos syndromeStructural relationships of SD1 and SD2 among primates, PWWP1 and NSL modelling A) SD1 structural relationships among primates. Super domain 1 is formed by the PWWP1 domain. M. musculus lacks the complete region and was excluded from the analysis. Homo sapiens separates from the rest of the primates, suggest a unique structure. B) SD2 structural relationships among analyzed species. Super domain 2 is formed by their central catalytic core of the protein, the SET domain. S. apella localized above of the outgroup. The rest of the species grouped in 3 clades. Clade A included H. sapiens, P. troglodytes and C. syrichta. Clade B grouped P. tephrosceles, M. mulatta, H. Moloch, P. abeli and O. garnettii in an ascending formation. Clade C included G. gorilla and M. murinus. C) The PWWP1 structure is composed of a five stranded beta barrel followed by a helix bundle. Left: O. garnettii, center: C. syrichta, right: human. The progressive changes between species suggest a complex evolution. D) NSLs distribution on NSD1 surface. Green: NSL1, cyan: NSL2 and orange NSL3. The three NSL have a triangular distribution around the surface allowing them to interact with other proteinsBack to article page