Fig. 2

Violin-swarm plots show allele frequencies for the Slovak NIPT and WES data and NFE data. Statistical significance is labeled with *, median with ♦. A2: Critically ill vs. population controls (45 risk variants). Statistics: median_W = 0.278; sd_W = 205; median_sN = 0.182, sd_sN = 0.186; median_N = 0.217, sd_N = 0.198; Mann–Whitney U test (WES vs. Slovak NIPT): p-value = 0.06510; Mann–Whitney U test (WES vs. NFE): p-value = 0.05363. B1: Hospitalized COVID-19 vs. non-hospitalized COVID-19 (13 risk variants). Statistics: median_W = 0.389; sd_W = 0.321; median_sN = 0.386, sd_sN = 0.297; median_N = 0.326, sd_N = 0.312; Mann–Whitney U test: WES vs. Slovak NIPT: p-value = 0.41863; WES vs. NFE: p-value = 0.22057. B2: Hospitalized COVID-19 vs population controls (51 risk variants). Statistics: median_W = 0.278; sd_W = 0.179; median_sN = 0.181, sd_sN = 0.181; median_N = 0.217, sd_N = 0.176; Mann–Whitney U test: WES vs. slovak NIPT: p-value = 0.04538; WES vs. NFE: p-value = 0.01872. C2: Reported SARS-CoV-2 infections vs. population controls (52 risk variants). Statistics: median_W = 0.204; sd_W = 0.21; median_sN = 0.177, sd_sN = 0.207; median_N = 0.176, sd_N = 0.209; Mann–Whitney U test: WES vs. slovak NIPT: p-value = 0.26942; WES vs. NFE: p-value = 0.12153; sd—standard deviation, sN—Slovak NIPT, W—WES—whole-exome sequencing data from deceased patients, NFE—Non-Finnish European population from the gnomAD database