Table 1 The total number of risk variants that were common across the individual comparative analysis (between NIPT, WES data and variants found in publications and individual HGI groups). *Comparison results from NIPT/WES/NFE/pub or HGI data/QCI analysis published in Results; ** Comparison results from NFE/WES/pub or HGI data/QCI analysis published in supplementary files; *** % of variants from comparison total number of NIPT/WES/Covid-19 HGI risk variants to the total number of risk variants in HGI group; **** % of variants from comparison number of WES/NFE/QCI/pub or HGI data risk variants to the total number of risk variants in comparison: WES/NFE/pub or HGI data; ***** % of variants from comparison number of NIPT/WES/NFE/QCI/pub or HGI data risk variants to the total number of risk variants in comparison: NIPT/WES/pub or HGI data
|  | Source of data | The total number of all variants (publications)/The total number of missense risk variants (COVID-19 HGI Group) | The number of risk variants in comparison: WES/NFE ** | The number of risk variants in comparison: NIPT/WES/pub or HGI data * (in parentheses ***) | QCI analysis—infection group (376 risk variants) | QCI analysis—critical group (1738 risk variants) | ||
|---|---|---|---|---|---|---|---|---|
Risk variants in comparison: WES/NFE/pub or HGI data ** (in parentheses ****) | Risk variants in comparison: NIPT/WES/NFE/pub or HGI data * (in parentheses *****) | Risk variants in comparison: WES/NFE/pub or HGI data ** (in parentheses ****) | Risk variants in comparison: NIPT/WES/NFE/pub or HGI data * (in parentheses *****) | |||||
Publications (pub) | I: infection | 1,745,372 | 208 | 103 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
II: severity | 277,165 | 154 | 96 | 0 (0%) | 0 (0%) | 14 (9.1%) | 7 (7.3%) | |
III: respiratory failure | 3,076,573 | 437 | 245 | 0 (0%) | 0 (0%) | 43 (9.8%) | 22 (9%) | |
COVID-19 HGI group (HGI) | A2: critically ill Covid-19 + vs. population | 62 | 51 | 45 (72.6%) | 3 (5.9%) | 2 (4.4%) | 1 (2%) | 1 (2.2%) |
B1: hospitalized Covid-19 + vs. non-hospitalized Covid-19 +  | 16 | 13 | 13 (81.3%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
B2: hospitalized Covid-19 + vs. population | 72 | 58 | 51 (70.8%) | 3 (5.2%) | 2 (3.9%) | 1 (1.7%) | 1 (2%) | |
C2: reported SARS-CoV-2 infected vs. population | 83 | 63 | 52 (62.7%) | 0 (0%) | 0 (0%) | 13 (20.6%) | 9 (17.3%) | |