Evaluation and limitations of different approaches among COVID-19 fatal cases using whole-exome sequencing data

BMC Genomics

Table 2 Risk variants with a significant difference (after the Bonferroni correction) in allele distribution of WES data from patients who died of Covid-19 and the control data of the Slovak NIPT (W/sN) and NFE (W/N). sig—significance: *—p-value < 0.05, **—significant after the Bonferroni correction

					Fisher's exact test p-values in WES/Slovak NIPT (W/sN) and the WES/NFE comparisons (W/N)
					Publications												COVID-19 HGI browser
					Infection				Disease severity				Respiratory failure				A2: critically ill vs. pop				C2: reported infect. vs. pop
	Variant ID	Risk variant	Gene	Consequence	sig	W/sN	sig	W/N	sig	W/sN	sig	W/N	sig	W/sN	sig	W/N	sig	W/sN	sig	W/N	sig	W/sN	sig	W/N
1	6–31,117,187-T-C	rs3130984	PSORS1C1	Missense variant													**	0.000056		0.356741
2	9–133,255,801-C-T	rs8176749	ABO	Non coding transcript exon variant						0.106383	**	0.000253
3	9–133,255,928-C-G	rs8176747	ABO	Missense variant						0.575117	**	0.000253										0.575117	**	0.000253
4	9–133,255,935-G-T	rs8176746	ABO	Missense variant						0.258419	**	0.000252										0.258419	**	0.000252
5	9–133,256,028-C-T	rs8176743	ABO	Missense variant					*	0.027003	**	0.000253									*	0.027003	**	0.000253
6	9–133,256,074-G-A	rs8176741	ABO	Non coding transcript exon variant						0.237448	**	0.000262
7	9–133,256,205-G-C	rs7853989	ABO	Missense variant						0.363999	**	0.000252										0.363999	**	0.000252
8	9–133,255,635-C-T	rs8176751	ABO	Non coding transcript exon variant					*	0.026342	**	0.000246
9	14–104,772,267-C-T	rs2498800	AKT1	Intron variant									**	0.000035		0.376467
10	17–1,728,046-TGAG-T	rs35048651	WDR81	5 Prime UTR variant	**	0.000005		0.136225

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