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Table 1 Ten most increased proteins and ten most decreased proteins post-sepsis compared to the sham

From: Identification of biomarkers and therapeutic targets related to Sepsis-associated encephalopathy in rats by quantitative proteomics

NO

Uniprot accession

Gene symbol

Protein name

Location

Ratio

p value

1

Q68FY4_RAT

Gc

GC

Extracellular region

2.1

0.006

2

A0A0G2K9Q3_RAT

Naa25

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Cytosol

1.1

0.038

3

HEM6_RAT

Cox

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Mitochondrion

0.9

0.003

4

A2MG_RAT

A2m

Alpha-2-macroglobulin

Extracellular region

0.9

0.008

5

CL043_RAT

Custos

Protein CUSTOS

Nucleus

0.9

0.047

6

Q4VFZ4_RAT

Katnb1

Katanin p80 WD40 repeat-containing subunit B1

Cytoskeleton

0.8

0.047

7

MAVS_RAT

Mavs

Mitochondrial antiviral-signaling protein

Mitochondrion

0.8

0.028

8

A0A0G2K0K8_RAT

Ralgapb

Ral GTPase-activating protein subunit beta

 

0.7

0.049

9

B3IYD2_RAT

Ufc1

Ubiquitin-fold modifier-conjugating enzyme 1

 

0.7

0.027

10

B5DFI3_RAT

Ap1s1

AP complex subunit sigma

Cytosol

0.7

0.039

11

D3ZIP8_RAT

Endod1

Uncharacterized protein

 

-0.7

0.030

12

D4A4F9_RAT

Stum

RCG20461

Membrane

-0.7

0.020

13

M0R7R2_RAT

LOC683897

Similar to Protein C6orf203

Mitochondrion

-0.7

0.020

14

CCD32_RAT

Ccdc32

Coiled-coil domain-containing protein 32

 

-0.7

0.020

15

HSDL2_RAT

Hsdl2

Hydroxysteroid dehydrogenase-like protein 2

Peroxisome

-0.6

0.020

16

MYO1D_RAT

Myo1d

Unconventional myosin-Id

 

-0.5

0.000

17

CAMP2_RAT

Camsap2

Calmodulin-regulated spectrin-associated protein 2

 

-0.5

0.000

18

CPLX2_RAT

Cplx2

Complexin-2

 

-0.5

0.000

19

A0A0G2K7 × 3_RAT

Nucks1

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

 

-0.5

0.000

20

Q5I0F0_RAT

Drg1

Developmentally-regulated GTP-binding protein 1

 

-0.5

0.038

  1. The table shows proteins that are altered after sepsis and the level of alteration is expressed as log2 of the iTRAQ ratios