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Table 1 Genes within selection peaks and flanking regions with functions that may be associated with hoof health were detected in the Baicha Iron Hoof horse

From: Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health

ECA

Region (Mb)

Top 0.1% SNPs (n)

CSS value

Cluster rank

Candidate genes

Gene function

1

119.28–119.72

88

2.83

1

CSPG4, PEAK1

Matrix metalloproteinase 2 activity

SEMA7A, CSK, PSTPIP1

Rheumatoid arthritis

7

16.77–17.08

56

2.71

2

GUCY1A2

Rheumatoid arthritis

EXPH5

Inherited Skin Fragility

3

39.62–40.1

65

2.50

3

EMCN

Rheumatoid arthritis

3

20.14–21.01

104

2.34

5

WWP2

Plantar fibromatosis

TERF2

Dyskeratosis congenita

PSMD7

Ankylosing spondylitis

NQO1

Injury and inflammation

NOB1

Osteosarcoma

NFAT5

Inflammatory arthritis

HAS3

Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin

31

12.94–13.16

53

2.28

6

OPRM1

Rheumatoid Arthritis