Table 2 The top 10 candidate drug compounds

LUCANTHONE CTD 00,006,227

1.52e-20

1.39e-17

CCNA2, TOP2A, CDC20, CCNB1, PLK1, CDK1, BUB1B, KIF11, BUB1, AURKB

Etoposide MCF7 DOWN

2.67e-20

1.39e-17

CCNA2, CDC20, CCNB1, PLK1, BUB1B, KIF11, BUB1, AURKB

Resveratrol MCF7 DOWN

1.81e-17

6.32e-15

CCNA2, TOP2A, CDC20, CCNB1, PLK1, BUB1B, KIF11, BUB1

Methotrexate MCF7 DOWN

6.29e-17

1.64e-14

CCNA2, TOP2A, CDC20, CCNB1, PLK1, KIF11, BUB1

Fulvestrant CTD 00,002,740

4.54e-16

9.49e-14

CCNA2, TOP2A, CDC20, CCNB1, PLK1, CDK1, BUB1B, BUB1, AURKB

Troglitazone CTD 00,002,415

1.25e-15

2.17e-13

CCNA2, TOP2A, CDC20, CCNB1, PLK1, CDK1, BUB1B, KIF11, BUB1, AURKB

Trifluridine MCF7 DOWN

2.61e-15

3.89e-13

TOP2A, CDC20, CCNB1, PLK1, BUB1B, BUB1

0,173,570–0000 PC3 DOWN

1.43e-14

1.87e-12

CCNA2, CDC20, CCNB1, PLK1, KIF11, BUB1

Nocodazole BOSS

2.88e-14

3.35e-12

CCNB1, CDK1, BUB1B, KIF11, BUB1, AURKB

Ciclopirox MCF7 DOWN

2.33e-13

2.43e-11

TOP2A, CDC20, CCNB1, PLK1, BUB1B, BUB1