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Table 1 Relative mRNA abundance of selected differentially expressed genes in mammary parenchyma of late-pregnant gilts treated or not with domperidone

From: Effects of sustained hyperprolactinemia in late gestation on the mammary parenchymal tissue transcriptome of gilts

Gene symbol

Treatments1

P-value

CTL

(n = 18)

T7

(n = 17)

T20

(n = 17)

Up-regulated genes

 ACKR2

0.19 (0.03)b

0.28 (0.04)b

3.08 (0.52)a

<  0.001

 ANPEP

0.37 (0.04)b

0.34 (0.03)b

2.56 (0.45)a

<  0.001

 BHLHE40

0.49 (0.08)b

0.46 (0.04)b

2.14 (0.20)a

<  0.001

 CD14

0.27 (0.06)b

0.38 (0.05)b

2.20 (0.27)a

<  0.001

 CD36

0.56 (0.05)b

0.45 (0.05)b

2.12 (0.28)a

<  0.001

 CEBPD

0.41 (0.06)b

0.43 (0.05)b

2.32 (0.35)a

<  0.001

 CIDEA

0.13 (0.03)b

0.11 (0.02)b

3.25 (0.80)a

0.003

 ECM1

0.35 (0.06)b

0.37 (0.04)b

2.32 (0.23)a

<  0.001

 EGF

0.22 (0.05)b

0.26 (0.04)b

2.92 (0.39)a

<  0.001

 LALBA

0.12 (0.03)b

0.14 (0.03)b

2.60 (0.49)a

<  0.001

 LRG1

0.14 (0.03)b

0.18 (0.04)b

2.52 (0.36)a

<  0.001

 SPP1

0.24 (0.09)b

0.33 (0.07)b

2.39 (0.44)a

<  0.001

 TC2N

0.54 (0.06)b

0.61 (0.05)b

1.89 (0.14)a

<  0.001

Down-regulated genes

 CAMK1G

1.64 (0.20)a

0.98 (0.10)b

0.27 (0.08)c

<  0.001

 CHODL

1.18 (0.13)a

1.11 (0.13)a

0.21 (0.05)b

<  0.001

 COL9A1

2.29 (0.45)a

0.49 (0.14)b

0.15 (0.04)c

<  0.001

 CXCR4

0.98 (0.07)a

1.08 (0.06)a

0.52 (0.06)b

<  0.001

 ERBB4

1.17 (0.14)a

0.92 (0.10)a

0.54 (0.09)b

0.001

 FMO2

1.34 (0.19)a

0.97 (0.18)a

0.30 (0.04)b

<  0.001

 NCALD

1.19 (0.07)a

1.08 (0.09)a

0.56 (0.06)b

<  0.001

 P2RX7

1.41 (0.12)a

0.88 (0.11)b

0.44 (0.07)c

<  0.001

 RCBTB1

1.27 (0.09)a

1.08 (0.09)a

0.54 (0.09)b

<  0.001

 RGS2

1.21 (0.14)a

1.11 (0.10)a

0.44 (0.04)b

<  0.001

 SCRG1

1.37 (0.18)a

0.99 (0.09)a

0.34 (0.06)b

<  0.001

 SHC4

1.08 (0.09)a

1.09 (0.08)a

0.73 (0.09)b

0.009

 TDRD1

1.44 (0.14) a

1.05 (0.09)b

0.19 (0.05)c

<  0.001

  1. 1CTL = control gilts; T7 = gilts receiving intramuscular injections of 0.5 mg/kg of domperidone from d90 to d 96 of gestation; T20 = gilts receiving intramuscular injections of 0.5 mg/kg of domperidone from d 90 to d 109 of gestation
  2. LSmeans are presented with their individual SEM
  3. a-cValues with different superscripts differ at P ≤ 0.05