Skip to main content
Fig. 3 | BMC Genomics

Fig. 3

From: Transcriptomic profiling of the developing brain revealed cell-type and brain-region specificity in a mouse model of prenatal stress

Fig. 3

Integrative analysis of bulk RNA-seq and scRNA-seq. (A-C) Cell-type enrichment analysis of differentially expressed genes. (A) t-SNE plot shows cluster assignments of cells using published scRNA-seq data in mouse fetal brain at E15.5. (B-C) t-SNE plots and cell-type enrichment score for (B) up- and (C) down-regulated DEGs (FDR < 0.05). Notice up-regulated DEGs are highly enriched in the radial glia, while for down-regulated DEGs are enriched in the neurons. (D) Cell-type deconvolution analysis. Bar graphs show cell fractions (neuron, radial glia, neuroblast, gliobalst, vascular cell) in the control and stressed fetal brains. Notice significant decrease of neuron and decrease of neuroblast in the stressed brain. N = 9 control, 7 stress. Mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. Unpaired t-test

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us