Table 3 Putative biosynthetic gene clusters found by antiSMASH from the genomes of Streptomyces sp. JH002, Streptomyces sp. JH34, Streptomyces sp. JH010, and Streptomyces sp. JH14. Only clusters with similarity (percentage of genes with significant BLAST hit) ≥ 60% are shown. Sm (%) = similarity percentage. NA = Metabolite function not fully established, or without therapeutic activity
Isolate | Cluster name | Sm (%) | Secondary metabolite function |
|---|---|---|---|
Streptomyces sp. JH002 | Ikarugamycin | 84 | Antimicrobial activity |
Ectoine | 100 | NA | |
Moomysin | 75 | NA | |
Nenestatin | 66 | NA | |
Desferrioxamine B | 60 | Iron chelator | |
Streptomyces sp. JH34 | Isorenieratene | 100 | NA |
Desferrioxamine B/ E | 100 | Iron chelator | |
Ectoine | 100 | NA | |
Melanin | 100 | NA | |
Sceliphrolactam | 92 | Antifungal metabolite | |
Coelichelin | 90 | Iron chelator | |
Spore pigment | 83 | NA | |
Chromomycin A3 | 88 | Antitumoral metabolite | |
Streptomyces sp. JH010 | Melanin | 100 | NA |
Ectoine | 100 | NA | |
Ectoine | 100 | NA | |
Isorenieratene | 100 | NA | |
Coelichelin | 90 | Iron chelator | |
Sceliphrolactam | 88 | Antifungal metabolite | |
Spore pigment | 83 | NA | |
Desferrioxamine B /E | 83 | Iron chelator | |
Terpene | 69 | NA | |
Carbapenem MM4550 | 65 | Antimicrobial activity | |
Streptomyces sp. JH14 | Desferrioxamine B | 100 | Iron chelator |
Naringenin | 100 | Antimicrobial, anti-inflammatory, and antitumoral metabolite | |
Amycomicin | 100 | Antimicrobial metabolite | |
Hopene | 84 | NA |