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Fig. 7 | BMC Genomics

Fig. 7

From: Combining a machine-learning derived 4-lncRNA signature with AFP and TNM stages in predicting early recurrence of hepatocellular carcinoma

Fig. 7

The relative expression of 4 lncRNAs in clinical HCC and paracancerous tissue samples (N = 44). (A) The expression of AC108463.1 was higher in HCC samples compared to paired paracancerous samples (P = 0.0021); (B) The expression of AF131217.1 was lower in HCC samples compared to paired paracancerous samples (P < 0.0001); (C) The expression of CMB9-22P13.1 was higher in HCC samples compared to paired paracancerous samples (P < 0.0001); (D) The expression of TMCC1-AS1 was higher in HCC samples compared to paired paracancerous samples (P = 0.0059). Statistical comparison was calculated by Wilcoxon test. (E) Multivariate cox analysis of the 4-lncRNA signature risk score, T stage and AFP with 2-year DFS in an external clinical cohort (N = 24). The 4-lncRNA signature risk score, T stage and AFP are independent risk indicators for 2-year DFS (P < 0.05); (F) 2-year DFS Kaplan-Meier curve in the clinical cohort (N = 24), the recurrence probability was higher in the high-risk group HCC patients than that in the low-risk group HCC patients (P < 0.0001). The significance was compared by log-rank test

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BMC Genomics

ISSN: 1471-2164

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