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Table 3 Bivariate and multivariate analysis for association of the + 936C/T 3’ UTR VEGF gene polymorphism with PE

From: No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda

Variable

Cases N = 125 n(%)

Controls N = 125 n(%)

Crude OR (95% CI)

P-value

Adjusted OR (95% CI)

P-value

Adjusted P-value

 + 936C/T polymorphism

 Present

15 (12.0)

10 (8.0)

1.56 (0.67–3.59)

0.3010

1.78 (0.65–4.91)

0.2640

1.0000

 Absent

110 (88.0)

115 (92.0)

1

 

1

  

HIV status

 Positive

3 (2.4)

9 (7.2)

0.33 (0.09–1.231)

0.0994

0.38 (0.09–1.52)

0.1699

1.0000

 Negative

122 (97.6)

116 (92.8)

1

 

1

  

Alcohol consumption

 Yes

10 (8.0)

8 (6.4)

1.29 (0.48–3.45)

0.6180

  

 No

114 (91.2)

117 (93.6)

1

    

 Missing data

1 (0.8)

0 (0.0)

     

Family history of PE

 Yes

9 (7.2)

1 (0.8)

9.00 (1.14–71.04)

0.0371

8.49 (1.00–71.76)

0.0520

0.3120

 No

116 (92.8)

122 (97.6)

1

 

1

  

 Missing data

0 (0.0)

2 (1.6)

     

Family history of hypertension

 Yes

47 (37.6)

25 (20.0)

2.57 (1.39–4.77)

0.0027

2.37 (1.12–5.01)

0.0185

0.1109

 No

78 (62.4)

100 (80.0)

1

 

1

  

Diagnosis with hypertension in previous pregnancy

 Yes

14 (11.2)

1 (0.8)

11.00 (1.42–85.2)

0.0217

  

 No

56 (44.8)

77 (61.6)

1

    

 Missing data

55 (44.0)

47 (37.6)

     

First pregnancy

 Yes

54

46

1.53 (0.80–2.94)

0.2000

  

 No

71

79

1

    

Type of pregnancy

 Multiple

6 (4.8)

1 (0.8)

6.00 (0.72–49.84)

0.0971

7.25 (0.84–62.94)

0.0722

0.4334

 Singleton

115 (92.0)

120 (96.0)

1

 

1

  

 Missing data

4 (3.2)

4 (3.2)

     

Family history of diabetes mellitus

 Yes

20 (16.0)

12 (9.6)

1.64 (0.77–3.47)

0.1980

0.99 (0.36–2.76)

0.9910

 

 No

105 (84.0)

113 (90.4)

1

 

1

  

Marital status

 Married

107 (85.6)

111 (88.8)

1.33 (0.63–2.82)

0.4510

  

 Single

18 (14.4)

14 (11.2)

1

    
  1. n number. Missing data was regarded as missing completely at random due to unavailability of required values on patient files. Adjusted P-value, Bonferroni correction