Table 1 Model performance of dbCNV and ClassifyCNV on ClinVar set
From: dbCNV: deleteriousness-based model to predict pathogenicity of copy number variations
metrics | dbCNV | Â | ClassifyCNV | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | loss | Â | gain | Â | loss | Â | gain | |||||||||||||||||
| Â | P | LP | VUS | LB | B | Â | P | LP | VUS | LB | B | Â | P | LP | VUS | LB | B | Â | P | LP | VUS | LB | B | Â |
Balance accuracy | 0.69 | 0.59 | 0.60 | 0.50 | 0.74 | Â | 0.90 | 0.82 | 0.89 | 0.85 | 0.90 | Â | 0.53 | 0.45 | 0.67 | 0.50 | 0.17 | Â | 0.50 | 0.50 | 0.52 | 0.50 | 0.59 | Â |
Sensitivity | 0.68 | 0.18 | 0.20 | 0 | 0.85 | Â | 0.80 | 0.65 | 0.83 | 0.69 | 0.95 | Â | 0.06 | 0.16 | 0.95 | 0 | 0.33 | Â | 0.01 | 0.002 | 0.98 | 0 | 0.19 | Â |
Specificity | 0.69 | 0.99 | 0.99 | 1 | 0.64 | Â | 0.99 | 0.99 | 0.95 | 0.99 | 0.83 | Â | 0.99 | 0.74 | 0.38 | 1 | 0.01 | Â | 0.99 | 0.99 | 0.05 | 1 | 0.99 | Â |