Table 3 Association between circulating protein levels and RA
Proteins | Estimatea | Standard Errora | P values | ||||
|---|---|---|---|---|---|---|---|
IVW | Weighted median | MR-Egger | Intercept | MR-PRESSO | |||
2014 GWAS | |||||||
 CFB | −0.2974 | 0.1569 | 5.80E-02 | 1.10E-08 | 9.61E-02 | 5.24E-01 | 1.92E-02 |
 CREB3L4 | −0.0050 | 0.1552 | 9.74E-01 | 1.19E-03 | 3.63E-01 | 2.31E-01 | 3.22E-01 |
 GZMA | 0.1391 | 0.0699 | 4.65E-02 | 1.59E-05 | 7.47E-01 | 6.91E-01 | 4.45E-02 |
 HLA-DQA2 | 0.8919 | 0.1954 | 5.04E-06 | 8.41E-18 | 1.16E-03 | 2.38E-01 | 1.04E-03 |
 IL21 | 0.5653 | 0.2303 | 1.41E-02 | 2.04E-01 | 4.13E-05 | 2.88E-03 | 3.97E-02 |
 LRPAP1 | −0.2514 | 0.0899 | 5.19E-03 | 7.75E-11 | 1.50E-02 | 4.48E-01 | 3.48E-04 |
 PRSS3 | −1.0627 | 0.1774 | 2.08E-09 | 1.18E-20 | 1.51E-14 | 1.31E-05 | 6.30E-05 |
 TFF3 | −0.2922 | 0.1285 | 2.29E-02 | 2.78E-01 | 3.52E-10 | 2.70E-07 | 4.21E-02 |
 USP25 | −0.4214 | 0.1646 | 1.05E-02 | 1.36E-16 | 3.94E-02 | 6.34E-01 | 3.03E-03 |
2021 GWAS | |||||||
 CFB | −0.2219 | 0.0770 | 3.94E-03 | 8.53E-12 | 6.94E-05 | 1.46E-02 | 1.20E-03 |
 CREB3L4 | −0.1199 | 0.1537 | 4.35E-01 | 9.25E-08 | 4.01E-01 | 6.48E-01 | 9.49E-04 |
 GZMA | −0.0877 | 0.1211 | 4.69E-01 | 7.08E-01 | 9.35E-01 | 7.12E-01 | 4.80E-01 |
 HLA-DQA2 | 0.2146 | 0.0867 | 1.33E-02 | 4.76E-02 | 1.67E-05 | 1.31E-03 | 2.67E-02 |
 IL21 | 0.1706 | 0.1502 | 2.56E-01 | 3.76E-01 | 1.05E-01 | 2.11E-01 | 2.77E-01 |
 LRPAP1 | −0.1743 | 0.0566 | 2.06E-03 | 5.86E-07 | 5.96E-03 | 3.31E-01 | 2.53E-03 |
 PRSS3 | −0.4078 | 0.2043 | 4.70E-02 | 6.02E-01 | 3.34E-03 | 2.60E-02 | 6.56E-02 |
 TFF3 | −0.2198 | 0.0999 | 2.78E-02 | 6.87E-01 | 2.90E-06 | 1.25E-04 | 4.28E-02 |
 USP25 | −0.1082 | 0.2052 | 5.98E-01 | 1.25E-09 | 4.88E-01 | 6.39E-01 | 2.98E-01 |