Fig. 7

REACTOME analysis of protein changes up to 28 days after TBI. Using PANTHER gene expression analysis tool, selecting for Macaca mulatta organism, using the statistical overrepresentation test (Reactome pathways) and Macaca mulatta reference whole genome, then selecting Fisher’s exact test and Bonferroni correction for multiple testing, the REACTOME categories that passed the corrected Bonferroni p-value cut off of 0.05 are shown below. Next, we merged the list and used VLOOKUP in Microsoft excel to sort the Bonferroni p-values in ascending order at the 3 time points as shown. The color scale indicated the range of Bonferroni p-values from deep green (10^–36) to yellow (10^–2) for these pathways. Processes related to immune system, platelet and neutrophil degranulation were significant at all times at the protein level. The lower part of the heatmap are processes that were significant starting at day 6 and then also at the latest 28-day time point