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Table 2 Summary for differences in gene expression (DGE) involved in malathion resistance in Culex quinquefasciatus (FDR < 0.05 in both comparisons between WI group versus CO group and between MR group versus MS group)

From: Potential key genes involved in metabolic resistance to malathion in the southern house mosquito, Culex quinquefasciatus, and functional validation of CYP325BC1 and CYP9M12 as candidate genes using RNA interference

CPIJ annotation1

Gene name

Gene location

(Sense/ Non-sense)2

Log FC3

(WI versus CO)4

Log FC3

(MR versus MS)4

CPIJ002663

Glutathione S-transferase 1–1

DS231848: 92,100 − 92,714 (+)

0.495483867

-1.18997411

CPIJ002786

carboxylesterase

DS231858: 39,753 − 45,680 (-)

-0.587412839

1.856624645

CPIJ005204

Peptide methionine sulfoxide reductase msrA

DS231920: 88,341 − 89,385 (-)

-1.390427104

3.475540072

CPIJ006160

Glutathione s-transferase

DS231921: 397,822 − 412,644 (-)

0.968180082

-1.959035654

CPIJ010231

cytochrome P450 12F9 (CYP12F9)

DS232091: 529,206–531,135 (-)

-0.271299583

0.84866247

CPIJ010480

cytochrome P450 4J20 (CYP4J20)

DS232089: 494,713 − 496,416 (+)

2.187784633

1.047702497

CPIJ012470

cytochrome P450 9AL1 (CYP9AL1)

DS232204: 402,930 − 405,046 (+)

2.07877162

1.193657009

CPIJ014219

cytochrome P450 9M10-de1b (CYP9M10-de1b)

DS232322: 166,391 − 170,209 (+)

-1.257222031

1.123581855

CPIJ014220

cytochrome P450 9M12 (CYP9M12)

DS232322: 170,566 − 172,216 (+)

0.328056599

1.833454196

CPIJ015958

cytochrome P450 325BC1 (CYP325BC1)

DS232542: 95,297 − 97,020 (+)

0.852001468

1.373485365

CPIJ018565

Peptide methionine sulfoxide reductase

DS233029: 61,489 − 62,536 (-)

1.300742526

3.308572035

CPIJ018630

Glutathione S-transferase 1–1

DS233036: 40,439 − 41,178 (-)

1.855584899

-1.096468825

  1. 1CPIJ = Culex quinquefasciatus Johannesburg
  2. 2Gene location, as described in VectorBase, (S/NS) = Sense = “+” and Non-sense = “-” strand
  3. 3 Log FC = Log Fold change (log2FC calculated by edgeR), positive values represent up-regulated gene expression and negative values represent down-regulated gene expression
  4. 4WI, CO, MR, MS = mosquito strain sub-types representing wild, colony, malathion resistant and malathion susceptible