Fig. 3

Construction of the prognostic signature. (A) The univariate Cox regression analysis of the six differentially expressed miRNAs indicates that has-miR-200a-5p, has-miR-223-3p, and has-miR-500a-3p were correlated with the survival times of patients with ccRCC (P < 0.05). (B) The results of multivariate Cox regression analysis of the six differentially expressed miRNAs are similar to those of the univariate analysis (P < 0.05). (C) The univariate Cox regression analysis of the risk score and clinical characteristics reveals that the tumor grade, tumor stage, and TNM classification were correlated with overall survival (P < 0.001). (D) The multivariate Cox regression analysis of the risk score and clinical characteristics indicates that the risk score is an independent prognostic factor (P = 0.0035)