Fig. 5

Transcription Factor Binding at CRE. RELI enrichment logP-value of CRE enrichment across available transcription factor ChIP-Seq experiments in GEO [44]. Heatmaps of RNA expression [transcripts per million (TPM)] in resting human CD4+ T cells are displayed furthest right [35]. Transcription factor family is displayed adjacent to RNA expression. A The ChIP-Seq experiments with strongest relative enrichment in STARR-Seq enhancers are displayed, whereas B displays the top experiments with strongest relative enrichment in NRE. C Motif enrichment performed in HOMER de novo motifs in enhancers (predicted motif, p-value, and transcription factor name) and D in NREs [54]