Fig. 4

Causal effect of growth rate and birth weight on the adult body weight. A GWAS based on the 120-day body weight. The gray line represents the Bonferroni corrected significance threshold (-log10P = 8.59). The x-axis shows the physical positions of each marker along the chromosome, and the y-axis shows the - log10P values of SNPs. B, C and D Funnel plot displaying instrument strength (y-axis) plotted against causal effect estimates (x-axis) for SNPs associated with RGR B, AGR C, and birth weight D. Scatter plots displaying estimates of the association between each SNP and 120-day body weight (y-axis) against estimates of the association between each SNP and RGR B, AGR C, and birth weight D (x-axis). The error bars on each of the points indicated the 95% CI. The causal effect estimates of Inverse variance weighted, MR Egger, Simple mode, Weighted median, and Weighted mode were represented by solid lines in different colours