Table 3 The association between MTNR1B gene rs1387153 locus and type 2 diabetes among steelworkers
Gene | Gene Model | Genotype | Control group, n (%) | Case group, n(%) | Model 1 | Model 2 |
|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | |||||
MTNR1B gene rs1387153 locus | Codominant | C/C | 157 (34.8) | 72 (28.7) | 1.00 (ref) | 1.00 (ref) |
C/T | 230 (51.0) | 118 (47.0) | 1.12 (0.78–1.60) | 1.18 (0.81–1.71) | ||
T/T | 64 (14.2) | 61 (24.3) | 2.08 (1.33–3.25) | 1.96 (1.22–3.14) | ||
Dominant | C/C | 157 (34.8) | 72 (28.7) | 1.00 (ref) | 1.00 (ref) | |
C/T-T/T | 294 (65.2) | 179 (71.3) | 1.33 (0.95–1.86) | 1.36 (0.96–1.93) | ||
Recessive | C/C–C/T | 387 (85.8) | 190 (75.7) | 1.00 (ref) | 1.00 (ref) | |
T/T | 64 (14.2) | 61 (24.3) | 1.94 (1.31–2.87) | 1.78 (1.18–2.68) | ||
Overdominant | C/C-T/T | 221 (49.0) | 133 (53.0) | 1.00 (ref) | 1.00 (ref) | |
C/T | 230 (51.0) | 118 (47.0) | 0.85 (0.63–1.16) | 0.92 (0.66–1.27) | ||
Log-additive | –- | –- | –- | 1.40 (1.12–1.75) | 1.37 (1.09–1.73) |