Skip to main content

Table 4 Multiplicative and additive interaction between rotating night shift work and gene on risk of type 2 diabetes

From: Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study

Genotype

Factors

Control group, n

Case group, n

OR (95% CI)

P for multiplicative interaction

Model 1

Model 2

Model 1

Model 2

rs2119882

Rotating night shift work

    

0.652

0.562

T/T

No

38

12

1.00 (ref)

1.00 (ref)

  

C/T-C/C

No

67

20

0.95 (0.42–2.14)

1.03 (0.44–2.39)

  

T/T

Yes

115

86

2.37 (1.17–4.80)

2.36 (1.14–4.87)

  

C/T-C/C

Yes

231

133

1.82 (0.92–3.61)

1.85 (0.92–3.75)

  

RERI

  

-0.49 (-1.81–0.83)

-0.54 (-1.92–0.85)

  

AP

  

-0.27 (-0.89–0.36)

-0.29 (-0.94–0.36)

  

rs1387153

Rotating night shift work

    

0.069

0.054

C/C

No

27

11

1.00 (ref)

1.00 (ref)

  

C/T-T/T

No

78

21

0.66 (0.22–1.55)

0.62 (0.26–1.47)

  

C/C

Yes

130

61

1.15 (0.54–2.47)

1.04 (0.48–2.29)

  

C/T-T/T

Yes

216

158

1.80 (0.87–3.73)

1.64 (0.77–3.45)

  

RERI

  

1.15 (0.54–2.47)

0.98 (0.40–1.55)

  

AP

  

0.66 (0.28–1.55)

0.60 (0.07–1.12)

  

rs1801260

Rotating night shift work

    

0.729

0.639

T/T

No

92

26

1.00 (ref)

1.00 (ref)

  

C/T-C/C

No

13

6

1.63 (0.57–4.72)

1.66 (0.56–4.93)

  

T/T

Yes

295

178

2.14 (1.33–3.43)

2.08 (1.27–3.38)

  

C/T-C/C

Yes

51

41

2.85 (1.56–5.18)

2.60 (1.40–4.84)

  

RERI

  

0.07 (-1.97–2.12)

-0.14 (-2.23–1.95)

  

AP

  

0.03 (-0.69–0.74)

-0.05 (-0.87–0.76)

  
  1. Model 1: univariate analysis. Model 2: adjusted for age, sex, smoking status, drinking status, physical activity, DASH score, dyslipidaemia, hypertension, liver dysfunction, renal dysfunction and exposure to occupational hazards (high temperature, noise, dust and carbon monoxide (CO)). DASH dietary approaches to stop hypertension, RERI Relative excess risk due to interaction, AP Attributable proportion. Value in bold: it indicates that it is statistically significant