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Fig. 2 | BMC Genomics

Fig. 2

From: Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors

Fig. 2

Transcriptional changes indicated the association of inflammatory response with the conversion and aging of HepLPCs. A Correlation analysis (Both dot size and dot color represented the level of correlation). B PCA analysis. C Number of DEGs (padj <  = 0.05 and |log2(FoldChange)|> = 1). D Gene set enrichment analysis (GSEA) revealed that processes related to innate immune response, inflammatory response, and interleukin 6 production were repressed in HepLPC-P3 and activated in HepLPC-P10. E Heatmap showing the z-scores of log2-transformed expression values of SASP genes based on RNA-seq data. F RT-qPCR analysis of chemokine gene expression (*p < 0.1, **p < 0.01, ***p < 0.001)

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BMC Genomics

ISSN: 1471-2164

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