Fig. 2

Enriched canonical pathways identified using IPA in TBI treatment. Both up and downregulated genes in each comparison are represented here (Benjamini–Hochberg corrected p-value ≤ 0.05). Orange or shades of orange bars indicate the predicted activation state of the canonical pathway, and blue or lighter shades of the blue bar indicate a negative z-score and down-regulation of the pathway. Grey bars represent pathways with no predicted activity pattern. The ratio indicates the number of significantly enriched genes compared with the total number of genes associated with that canonical pathway