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Human and rodent genomics

Section edited by Leonid Bystrykh, Leonard Schalkwyck and Stefan Wiemann

This section covers the genome structure and function in humans, primates and rodents.

Page 22 of 22

  1. Content type: Research article

    Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP enzymes catalyze oxidative transformation leading to activa...

    Authors: Jared V Goldstone, Andrew G McArthur, Akira Kubota, Juliano Zanette, Thiago Parente, Maria E Jönsson, David R Nelson and John J Stegeman

    Citation: BMC Genomics 2010 11:643

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  2. Content type: Research article

    Monocyte-derived macrophages and dendritic cells (DCs) are important in inflammatory processes and are often used for immunotherapeutic approaches. Blood monocytes can be differentiated into macrophages and DC...

    Authors: Liina Tserel, Raivo Kolde, Ana Rebane, Kai Kisand, Tõnis Org, Hedi Peterson, Jaak Vilo and Pärt Peterson

    Citation: BMC Genomics 2010 11:642

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  3. Content type: Research article

    The Nile tilapia is the second most important fish in aquaculture. It is an excellent laboratory model, and is closely related to the African lake cichlids famous for their rapid rates of speciation. A suite o...

    Authors: Lucile Soler, Matthew A Conte, Takayuki Katagiri, Aimee E Howe, Bo-Young Lee, Chris Amemiya, Andrew Stuart, Carole Dossat, Julie Poulain, Jeremy Johnson, Federica Di Palma, Kerstin Lindblad-Toh, Jean-Francois Baroiller, Helena D'Cotta, Catherine Ozouf-Costaz and Thomas D Kocher

    Citation: BMC Genomics 2010 11:636

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  4. Content type: Research article

    Macrosatellites are some of the largest variable number tandem repeats in the human genome, but what role these unusual sequences perform is unknown. Their importance to human health is clearly demonstrated by...

    Authors: Deanna C Tremblay, Graham Alexander Jr, Shawn Moseley and Brian P Chadwick

    Citation: BMC Genomics 2010 11:632

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  5. Content type: Research article

    When selecting mates, many vertebrate species seek partners with major histocompatibility complex (MHC) genes different from their own, presumably in response to selective pressure against inbreeding and towar...

    Authors: Pouya Khankhanian, Pierre-Antoine Gourraud, Stacy J Caillier, Adam Santaniello, Stephen L Hauser, Sergio E Baranzini and Jorge R Oksenberg

    Citation: BMC Genomics 2010 11:626

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  6. Content type: Research article

    Infestation of ovine skin with the ectoparasitic mite Psoroptes ovis results in a rapid cutaneous immune response, leading to the crusted skin lesions characteristic of sheep scab. Little is known regarding the m...

    Authors: Stewart TG Burgess, David Frew, Francesca Nunn, Craig A Watkins, Tom N McNeilly, Alasdair J Nisbet and John F Huntley

    Citation: BMC Genomics 2010 11:624

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  7. Content type: Research article

    Marbling (intramuscular fat) is a valuable trait that impacts on meat quality and an important factor determining price of beef in the Korean beef market. Animals that are destined for this high marbling marke...

    Authors: Seung-Hwan Lee, Cedric Gondro, Julius van der Werf, Nam-Kuk Kim, Da-jeong Lim, Eung-Woo Park, Sung-Jong Oh, John P Gibson and John M Thompson

    Citation: BMC Genomics 2010 11:623

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  8. Content type: Research article

    The chicken karyotype is composed of 39 chromosome pairs, of which 9 still remain totally absent from the current genome sequence assembly, despite international efforts towards complete coverage. Some others ...

    Authors: Romain Solinhac, Sophie Leroux, Svetlana Galkina, Olympe Chazara, Katia Feve, Florence Vignoles, Mireille Morisson, Svetlana Derjusheva, Bertrand Bed'hom, Alain Vignal, Valérie Fillon and Frédérique Pitel

    Citation: BMC Genomics 2010 11:616

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  9. Content type: Research article

    Sexual dimorphism in brain gene expression has been recognized in several animal species. However, the relevant regulatory mechanisms remain poorly understood. To investigate whether sex-biased gene expression...

    Authors: Björn Reinius, Chengxi Shi, Liu Hengshuo, Kuljeet Singh Sandhu, Katarzyna J Radomska, Glenn D Rosen, Lu Lu, Klas Kullander, Robert W Williams and Elena Jazin

    Citation: BMC Genomics 2010 11:614

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  10. Content type: Research article

    Dysregulated expression of microRNAs (miRNAs) has been previously observed in human cancer tissues and shown promise in defining tumor status. However, there is little information as to if or when expression c...

    Authors: Zhiguang Li, William S Branham, Stacey L Dial, Yexun Wang, Lei Guo, Leming Shi and Tao Chen

    Citation: BMC Genomics 2010 11:609

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  11. Content type: Research article

    Adenosine to inosine (A-to-I) RNA-editing is an essential post-transcriptional mechanism that occurs in numerous sites in the human transcriptome, mainly within Alu repeats. It has been shown to have consisten...

    Authors: Shoshana Greenberger, Erez Y Levanon, Nurit Paz-Yaacov, Aviv Barzilai, Michal Safran, Sivan Osenberg, Ninette Amariglio, Gideon Rechavi and Eli Eisenberg

    Citation: BMC Genomics 2010 11:608

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  12. Content type: Research article

    Recent studies in pigs have detected copy number variants (CNVs) using the Comparative Genomic Hybridization technique in arrays designed to cover specific porcine chromosomes. The goal of this study was to id...

    Authors: Yuliaxis Ramayo-Caldas, Anna Castelló, Romi N Pena, Estefania Alves, Anna Mercadé, Carla A Souza, Ana I Fernández, Miguel Perez-Enciso and Josep M Folch

    Citation: BMC Genomics 2010 11:593

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  13. Content type: Research article

    The current study focused on the extent genetic diversity within a species (Mus musculus) affects gene co-expression network structure. To examine this issue, we have created a new mouse resource, a heterogeneous...

    Authors: Ovidiu D Iancu, Priscila Darakjian, Nicole AR Walter, Barry Malmanger, Denesa Oberbeck, John Belknap, Shannon McWeeney and Robert Hitzemann

    Citation: BMC Genomics 2010 11:585

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  14. Content type: Research article

    Two year cancer bioassays conducted by the National Toxicology Program have shown chronic exposure to dioxin-like compounds (DLCs) to lead to the development of both neoplastic and non-neoplastic lesions in th...

    Authors: Bladimir J Ovando, Corie A Ellison, Chad M Vezina and James R Olson

    Citation: BMC Genomics 2010 11:583

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  15. Content type: Research article

    Genetic analysis of transcriptional profiles is a promising approach for identifying and dissecting the genetics of complex traits like meat performance. Accordingly, expression levels obtained by microarray a...

    Authors: Siriluck Ponsuksili, Eduard Murani, Manfred Schwerin, Karl Schellander and Klaus Wimmers

    Citation: BMC Genomics 2010 11:572

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  16. Content type: Research article

    Rainbow trout are important fish for aquaculture and recreational fisheries and serves as a model species for research investigations associated with carcinogenesis, comparative immunology, toxicology and evol...

    Authors: Mohamed Salem, Caird E Rexroad III, Jiannan Wang, Gary H Thorgaard and Jianbo Yao

    Citation: BMC Genomics 2010 11:564

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  17. Content type: Research article

    Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is imp...

    Authors: Ran Li, Anding Zhang, Bo Chen, Liu Teng, Ya Wang, Huanchun Chen and Meilin Jin

    Citation: BMC Genomics 2010 11:556

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  18. Content type: Research article

    Japanese flounder (Paralichthys olivaceus) is one of the most economically important marine species in Northeast Asia. Information on genetic markers associated with quantitative trait loci (QTL) can be used in b...

    Authors: Cecilia Castaño-Sánchez, Kanako Fuji, Akiyuki Ozaki, Osamu Hasegawa, Takashi Sakamoto, Kagayaki Morishima, Ichiro Nakayama, Atsushi Fujiwara, Tetsuji Masaoka, Hiroyuki Okamoto, Kengo Hayashida, Michihira Tagami, Jun Kawai, Yoshihide Hayashizaki and Nobuaki Okamoto

    Citation: BMC Genomics 2010 11:554

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  19. Content type: Research article

    Thoroughbred horses have been selected for traits contributing to speed and stamina for centuries. It is widely recognized that inherited variation in physical and physiological characteristics is responsible ...

    Authors: Emmeline W Hill, Beatrice A McGivney, Jingjing Gu, Ronan Whiston and David E MacHugh

    Citation: BMC Genomics 2010 11:552

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  20. Content type: Research article

    The pivotal role of stress in the precipitation of psychiatric diseases such as depression is generally accepted. This study aims at the identification of genes that are directly or indirectly responding to st...

    Authors: Amalia Tsolakidou, Ludwig Czibere, Benno Pütz, Dietrich Trümbach, Markus Panhuysen, Jan M Deussing, Wolfgang Wurst, Inge Sillaber, Rainer Landgraf, Florian Holsboer and Theo Rein

    Citation: BMC Genomics 2010 11:546

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  21. Content type: Research article

    Macrophages play essential roles in both innate and adaptive immune responses. Bacteria require endotoxin, a complex lipopolysaccharide, for outer membrane permeability and the host interprets endotoxin as a s...

    Authors: Ceren Ciraci, Christopher K Tuggle, Michael J Wannemuehler, Dan Nettleton and Susan J Lamont

    Citation: BMC Genomics 2010 11:545

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  22. Content type: Research article

    There was a large scale outbreak of the highly pathogenic porcine reproductive and respiratory syndrome (PRRS) in China and Vietnam during 2006 and 2007 that resulted in unusually high morbidity and mortality ...

    Authors: Shuqi Xiao, Delin Mo, Qiwei Wang, Jianyu Jia, Limei Qin, Xiangchun Yu, Yuna Niu, Xiao Zhao, Xiaohong Liu and Yaosheng Chen

    Citation: BMC Genomics 2010 11:544

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  23. Content type: Research article

    The genomes of salmonids are considered pseudo-tetraploid undergoing reversion to a stable diploid state. Given the genome duplication and extensive biological data available for salmonids, they are excellent ...

    Authors: Nicole L Quinn, Keith A Boroevich, Krzysztof P Lubieniecki, William Chow, Evelyn A Davidson, Ruth B Phillips, Ben F Koop and William S Davidson

    Citation: BMC Genomics 2010 11:539

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  24. Content type: Research article

    In the past, molecular mechanisms that drive the initiation of an inflammatory response have been studied intensively. However, corresponding mechanisms that sustain the expression of inflammatory response gen...

    Authors: Astrid Riehl, Tobias Bauer, Benedikt Brors, Hauke Busch, Regina Mark, Julia Németh, Christoffer Gebhardt, Angelika Bierhaus, Peter Nawroth, Roland Eils, Rainer König, Peter Angel and Jochen Hess

    Citation: BMC Genomics 2010 11:537

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  25. Content type: Research article

    miRNAs are small, non-coding RNA molecules that mainly act as negative regulators of target gene messages. Due to their regulatory functions, they have lately been implicated in several diseases, including mal...

    Authors: Ludwig Christian G Hinske, Pedro AF Galante, Winston P Kuo and Lucila Ohno-Machado

    Citation: BMC Genomics 2010 11:533

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  26. Content type: Research article

    Cellular senescence is a major barrier to tumour progression, though its role in pathogenesis of cancer and other diseases is poorly understood in vivo. Improved understanding of the degree to which latent sen...

    Authors: Kyle Lafferty-Whyte, Alan Bilsland, Claire J Cairney, Lorna Hanley, Nigel B Jamieson, Nadia Zaffaroni, Karin A Oien, Sharon Burns, Jon Roffey, Susan M Boyd and W Nicol Keith

    Citation: BMC Genomics 2010 11:532

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  27. Content type: Research article

    The construction of genetic linkage maps in free-living populations is a promising tool for the study of evolution. However, such maps are rare because it is difficult to develop both wild pedigrees and corres...

    Authors: Jocelyn Poissant, John T Hogg, Corey S Davis, Joshua M Miller, Jillian F Maddox and David W Coltman

    Citation: BMC Genomics 2010 11:524

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  28. Content type: Research article

    DNA methylation can regulate gene expression by modulating the interaction between DNA and proteins or protein complexes. Conserved consensus motifs exist across the human genome ("predicted transcription fact...

    Authors: Mun-Kit Choy, Mehregan Movassagh, Hock-Guan Goh, Martin R Bennett, Thomas A Down and Roger SY Foo

    Citation: BMC Genomics 2010 11:519

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  29. Content type: Research article

    Despite rhabdoviral infections being one of the best known fish diseases, the gene expression changes induced at the surface tissues after the natural route of infection (infection-by-immersion) have not been ...

    Authors: Paloma Encinas, Miguel A Rodriguez-Milla, Beatriz Novoa, Amparo Estepa, Antonio Figueras and Julio Coll

    Citation: BMC Genomics 2010 11:518

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  30. Content type: Research article

    MicroRNAs (miRs or miRNAs) regulate several biological processes in the cell. However, evidence for miRNAs that control the differentiation program of specific neural cell types has been elusive. Recently, we ...

    Authors: Márcia M Aranha, Daniela M Santos, Joana M Xavier, Walter C Low, Clifford J Steer, Susana Solá and Cecília MP Rodrigues

    Citation: BMC Genomics 2010 11:514

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  31. Content type: Research article

    The large yellow croaker (Pseudosciaena crocea) is an economically important marine fish in China suffering from severe outbreaks of infectious disease caused by marine bacteria such as Aeromonas hydrophila (A. h...

    Authors: Yinnan Mu, Feng Ding, Peng Cui, Jingqun Ao, Songnian Hu and Xinhua Chen

    Citation: BMC Genomics 2010 11:506

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  32. Content type: Methodology article

    The analysis of expression quantitative trait loci (eQTL) is a potentially powerful way to detect transcriptional regulatory relationships at the genomic scale. However, eQTL data sets often go underexploited ...

    Authors: Jacob J Michaelson, Rudi Alberts, Klaus Schughart and Andreas Beyer

    Citation: BMC Genomics 2010 11:502

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  33. Content type: Research article

    A large proportion of pregnancy losses occur during the pre-implantation period, when the developing embryo is elongating rapidly and signalling its presence to the maternal system. The molecular mechanisms th...

    Authors: Caroline G Walker, Susanne Meier, Mathew D Littlejohn, Klaus Lehnert, John R Roche and Murray D Mitchell

    Citation: BMC Genomics 2010 11:474

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  34. Content type: Research article

    Systematic research on fish immunogenetics is indispensable in understanding the origin and evolution of immune systems. This has long been a challenging task because of the limited number of deep sequencing t...

    Authors: Li-xin Xiang, Ding He, Wei-ren Dong, Yi-wen Zhang and Jian-zhong Shao

    Citation: BMC Genomics 2010 11:472

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  35. Content type: Research article

    The ovine Major Histocompatibility Complex (MHC) harbors clusters of genes involved in overall resistance/susceptibility of an animal to infectious pathogens. However, only a limited number of ovine MHC genes ...

    Authors: Jianfeng Gao, Ka Liu, Haibo Liu, Hugh T Blair, Gang Li, Chuangfu Chen, Pingping Tan and Runlin Z Ma

    Citation: BMC Genomics 2010 11:466

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  36. Content type: Research article

    The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells. The chemokine system is complex in that multiple chemokines can bin...

    Authors: Stephanie Widdison, Nazneen Siddiqui, Victoria Easton, Freya Lawrence, George Ashley, Dirk Werling, Michael Watson and Tracey J Coffey

    Citation: BMC Genomics 2010 11:439

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  37. Content type: Correspondence

    The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of...

    Authors: Alan L Archibald, Lars Bolund, Carol Churcher, Merete Fredholm, Martien AM Groenen, Barbara Harlizius, Kyung-Tai Lee, Denis Milan, Jane Rogers, Max F Rothschild, Hirohide Uenishi, Jun Wang and Lawrence B Schook

    Citation: BMC Genomics 2010 11:438

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