Skip to main content



Section edited by Scott Hemby

This section covers all aspects of high-throughput proteomics, experimental and analytical approaches to proteome analysis, mass spectrometry, and also metabolomics.

Page 1 of 4

  1. Content type: Research article

    Feed efficiency is one of the most important parameters that affect beef production costs. The energy metabolism of skeletal muscle greatly contributes to variations in feed efficiency. However, information re...

    Authors: Elisa B. Carvalho, Mateus P. Gionbelli, Rafael T. S. Rodrigues, Sarah F. M. Bonilha, Charles J. Newbold, Simone E. F. Guimarães, Walmir Silva, Lucas L. Verardo, Fabyano F. Silva, Edenio Detmann and Marcio S. Duarte

    Citation: BMC Genomics 2019 20:501

    Published on:

  2. Content type: Research article

    The pearl oyster Pinctada fucata martensii (Pfu.), widely cultured in the South China Sea, is a precious source of sea pearls and calcifying materials. A yellow shell variety of Pfu. was obtained after years of a...

    Authors: Meng Xu, Jing Huang, Yu Shi, Hua Zhang and Maoxian He

    Citation: BMC Genomics 2019 20:469

    Published on:

  3. Content type: Research article

    Herpetospermum pedunculosum (Ser.) Baill is annual scandent herbs. They are used in the treatment of piles, inflammation of the stomach and the intestines. It can survive the extreme environment of the Tibetan Pl...

    Authors: Yong Zhao, Fuling Xu, Jia Liu, Fachun Guan, Hong Quan and Fanjuan Meng

    Citation: BMC Genomics 2019 20:451

    Published on:

  4. Content type: Research article

    Salinization seriously threatens land use efficiency and crop yields across the world. Understanding the mechanisms plants use to protect against salt stress will help breeders develop salt-tolerant vegetable ...

    Authors: Yihua Zhan, Qingfei Wu, Yue Chen, Mengling Tang, Chendong Sun, Junwei Sun and Chenliang Yu

    Citation: BMC Genomics 2019 20:381

    Published on:

  5. Content type: Research article

    Lysine crotonylation, as a novel evolutionarily conserved type of post-translational modifications, is ubiquitous and essential in cell biology. However, its functions in tea plants are largely unknown, and th...

    Authors: Jianhao Sun, Chen Qiu, Wenjun Qian, Yu Wang, Litao Sun, Yusheng Li and Zhaotang Ding

    Citation: BMC Genomics 2019 20:340

    Published on:

  6. Content type: Methodology article

    Two-dimensional electrophoresis (2-DE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are widely used in plant proteomics research. However, these two techniques cannot be simultaneously satisfi...

    Authors: Xiang Jin, Liping Zhu, Chengcheng Tao, Quanliang Xie, Xinyang Xu, Lili Chang, Yanhua Tan, Guohua Ding, Hongbin Li and Xuchu Wang

    Citation: BMC Genomics 2019 20:285

    Published on:

  7. Content type: Research article

    Cotton leaf curl disease (CLCuD), caused by begomoviruses in association with satellite molecules, is a major threat to cotton production causing enormous losses to cotton crop in most of the cotton growing co...

    Authors: Razia Qadir, Zainul A. Khan, Dilip Monga and Jawaid A. Khan

    Citation: BMC Genomics 2019 20:274

    Published on:

  8. Content type: Research article

    Triple negative breast cancer (TNBC) is a malignancy with very poor prognosis, due to its aggressive clinical characteristics and lack of response to receptor-targeted drug therapy. In TNBC, immune-related pat...

    Authors: Fernando J. Velloso, Alexandre R. Campos, Mari C. Sogayar and Ricardo G. Correa

    Citation: BMC Genomics 2019 20:152

    Published on:

  9. Content type: Research article

    Colonization of deep-sea hydrothermal vents by most invertebrates was made efficient through their adaptation to a symbiotic lifestyle with chemosynthetic bacteria, the primary producers in these ecosystems. A...

    Authors: Camille Détrée, Iman Haddad, Emmanuelle Demey-Thomas, Joëlle Vinh, François H. Lallier, Arnaud Tanguy and Jean Mary

    Citation: BMC Genomics 2019 20:109

    Published on:

  10. Content type: Research article

    Bakanae disease, caused by the fungus Fusarium fujikuroi, occurs widely throughout Asia and Europe and sporadically in other rice production areas. Recent changes in climate and cropping patterns have aggravated ...

    Authors: Zhijuan Ji, Yuxiang Zeng, Yan Liang, Qian Qian and Changdeng Yang

    Citation: BMC Genomics 2019 20:91

    Published on:

  11. Content type: Research article

    Waterlogging is one of the main abiotic stresses that limit wheat production. Quantitative proteomics analysis has been applied in the study of crop abiotic stress as an effective way in recent years (e.g. sal...

    Authors: Rui Pan, Dongli He, Le Xu, Meixue Zhou, Chengdao Li, Chu Wu, Yanhao Xu and Wenying Zhang

    Citation: BMC Genomics 2019 20:60

    Published on:

  12. Content type: Software

    Accurate structural annotation of genomes is still a challenge, despite the progress made over the past decade. The prediction of gene structure remains difficult, especially for eukaryotic species, and is oft...

    Authors: Laetitia Guillot, Ludovic Delage, Alain Viari, Yves Vandenbrouck, Emmanuelle Com, Andrés Ritter, Régis Lavigne, Dominique Marie, Pierre Peterlongo, Philippe Potin and Charles Pineau

    Citation: BMC Genomics 2019 20:56

    Published on:

  13. Content type: Research article

    Streptococcus agalactiae (GBS) is a major pathogen of Nile tilapia, a global commodity of the aquaculture sector. The aims of this study were to evaluate protein expression in the main genotypes of GBS isolated f...

    Authors: Guilherme Campos Tavares, Felipe Luiz Pereira, Gustavo Morais Barony, Cristiana Perdigão Rezende, Wanderson Marques da Silva, Gustavo Henrique Martins Ferreira de Souza, Thiago Verano-Braga, Vasco Ariston de Carvalho Azevedo, Carlos Augusto Gomes Leal and Henrique César Pereira Figueiredo

    Citation: BMC Genomics 2019 20:11

    Published on:

  14. Content type: Research article

    Thiazolidinone derivatives show inhibitory activity (IC50) against the Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index. To disclose the target proteins of the thiazolidinone co...

    Authors: Diego Molina, Rodrigo Cossio-Pérez, Cristian Rocha-Roa, Lina Pedraza, Edwar Cortes, Alejandro Hernández and Jorge E. Gómez-Marín

    Citation: BMC Genomics 2018 19:856

    Published on:

  15. Content type: Research article

    Pyropia yezoensis is an important marine crop which, due to its high protein content, is widely used as a seafood in China. Unfortunately, red rot disease, caused by Pythium porphyrae, seriously damages P. yezoen...

    Authors: Sohrab Khan, Yunxiang Mao, Dong Gao, Sadaf Riaz, Zeeshan Niaz, Lei Tang, Sohaib Khan and Dongmei Wang

    Citation: BMC Genomics 2018 19:842

    Published on:

  16. Content type: Research article

    Wheat (Triticum aestivum L.) is one of the world’s most important grain crops. The amyloplast, a specialized organelle, is the major site for starch synthesis and storage in wheat grain. Understanding the metabol...

    Authors: Dongyun Ma, Xin Huang, Junfeng Hou, Ying Ma, Qiaoxia Han, Gege Hou, Chenyang Wang and Tiancai Guo

    Citation: BMC Genomics 2018 19:768

    Published on:

  17. Content type: Research article

    Databases of literature-curated protein-protein interactions (PPIs) are often used to interpret high-throughput interactome mapping studies and estimate error rates. These databases combine interactions across...

    Authors: R. Greg Stacey, Michael A. Skinnider, Jenny H. L. Chik and Leonard J. Foster

    Citation: BMC Genomics 2018 19:758

    Published on:

  18. Content type: Research article

    High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Ae...

    Authors: Dwight R Causey, Moritz A N Pohl, David A Stead, Samuel A M Martin, Christopher J Secombes and Daniel J Macqueen

    Citation: BMC Genomics 2018 19:719

    Published on:

  19. Content type: Research article

    Bacterial invasive infection and host immune response is fundamental to the understanding of pathogen pathogenesis and the discovery of effective therapeutic drugs. However, there are very few experimental stu...

    Authors: Suyu Mei, Erik K. Flemington and Kun Zhang

    Citation: BMC Genomics 2018 19:505

    Published on:

  20. Content type: Methodology article

    Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. Apoptosis proteins subcellular localization information is very impor...

    Authors: Bin Yu, Shan Li, Wenying Qiu, Minghui Wang, Junwei Du, Yusen Zhang and Xing Chen

    Citation: BMC Genomics 2018 19:478

    Published on:

  21. Content type: Research article

    Eukaryotic cells contain a huge variety of internally specialized subcellular compartments. Stoichiogenomics aims to reveal patterns of elements usage in biological macromolecules. However, the stoichiogenomic...

    Authors: Yu-Juan Zhang, Chengxu Zhu, Yiran Ding, Zheng-Wen Yan, Gong-Hua Li, Yang Lan, Jian-Fan Wen and Bin Chen

    Citation: BMC Genomics 2018 19:469

    Published on:

  22. Content type: Research article

    Genome wide association studies (GWAS) have helped identify large numbers of genetic loci that significantly associate with increased risk of developing diseases. However, translating genetic knowledge into un...

    Authors: Raffaele Ferrari, Demis A. Kia, James E. Tomkins, John Hardy, Nicholas W. Wood, Ruth C. Lovering, Patrick A. Lewis and Claudia Manzoni

    Citation: BMC Genomics 2018 19:452

    Published on:

  23. Content type: Research article

    Coexistence and transition of diverse sex determination strategies have been revealed in some ectothermic species, but the variation between males caused by different sex determination strategies and the under...

    Authors: Yao-Jun Zhu, Xi-Yin Li, Jun Zhang, Zhi Li, Miao Ding, Xiao-Juan Zhang, Li Zhou and Jian-Fang Gui

    Citation: BMC Genomics 2018 19:437

    Published on:

  24. Content type: Research article

    Rapid evolution of phosphorylation sites could provide raw materials of natural selection to fit the environment by rewiring the regulation of signal pathways. However, a large part of phosphorylation sites wa...

    Authors: Benpeng Miao, Qingyu Xiao, Weiran Chen, Yixue Li and Zhen Wang

    Citation: BMC Genomics 2018 19:431

    Published on:

  25. Content type: Research article

    Azadirachtin, one of the most promising botanical insecticides, has been widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1–4. Mitochondrial a...

    Authors: Benshui Shu, Jianwen Jia, Jingjing Zhang, Veeran Sethuraman, Xin Yi and Guohua Zhong

    Citation: BMC Genomics 2018 19:413

    Published on:

  26. Content type: Research article

    In avian species, liver is the main site of de novo lipogenesis, and hepatic lipid metabolism relates closely to adipose fat deposition. Using our fat and lean chicken lines of striking differences in abdomina...

    Authors: Wei Na, Yuan-Yuan Wu, Peng-Fei Gong, Chun-Yan Wu, Bo-Han Cheng, Yu-Xiang Wang, Ning Wang, Zhi-Qiang Du and Hui Li

    Citation: BMC Genomics 2018 19:384

    Published on:

  27. Content type: Research article

    Scallops possess striated and catch adductor muscles, which have different structure and contractile properties. The striated muscle contracts very quickly for swimming, whereas the smooth catch muscle can kee...

    Authors: Xiujun Sun, Zhihong Liu, Biao Wu, Liqing Zhou, Qi Wang, Wei Wu and Aiguo Yang

    Citation: BMC Genomics 2018 19:377

    Published on:

  28. Content type: Research article

    Midgut invasion, a major bottleneck for malaria parasites transmission is considered as a potential target for vector-parasite interaction studies. New intervention strategies are required to explore the midgu...

    Authors: Sonam Vijay, Ritu Rawal, Kavita Kadian, Jagbir Singh, Tridibesh Adak and Arun Sharma

    Citation: BMC Genomics 2018 19:337

    Published on:

  29. Content type: Research article

    Spike architecture mutants in tetraploid wheat (Triticum turgidum L., 2n = 28, AABB) have a distinct morphology, with parts of the rachis node producing lateral meristems that develop into ramified spikelete (RSs...

    Authors: Shulin Chen, Juan Chen, Fu Hou, Yigao Feng and Ruiqi Zhang

    Citation: BMC Genomics 2018 19:228

    Published on:

  30. Content type: Research article

    Protein lysine malonylation, a newly discovered post-translational modification (PTM), plays an important role in diverse metabolic processes in both eukaryotes and prokaryotes. Common wheat is a major global ...

    Authors: Jiabin Liu, Guangyuan Wang, Qi Lin, Wenxing Liang, Zhiqiang Gao, Ping Mu, Guiquan Li and Limin Song

    Citation: BMC Genomics 2018 19:209

    Published on:

  31. Content type: Research article

    Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19 °C over several weeks and have negative eff...

    Authors: Waldo G. Nuez-Ortín, Chris G. Carter, Peter D. Nichols, Ira R. Cooke and Richard Wilson

    Citation: BMC Genomics 2018 19:133

    Published on:

  32. Content type: Research article

    The growth of Inner Mongolian Cashmere goat skin hair follicle exhibits a periodic growth pattern. The hair growth cycle is distinguished as telogen, anagen, and catagen stages. The role of vimentin in the gro...

    Authors: Nai Rile, Zhihong Liu, Lixia Gao, Jingkai Qi, Meng Zhao, Yuchun Xie, Rui Su, Yanjun Zhang, Ruijun Wang, Jie Li, Hongmei Xiao and Jinquan Li

    Citation: BMC Genomics 2018 19:38

    Published on:

  33. Content type: Research article

    Chicken embryos are widely used as a model for studies of obesity; however, no detailed information is available about the dynamic changes of proteins during the regulation of adipose biology and metabolism. T...

    Authors: Mengling Peng, Shengnan Li, Qianian He, Jinlong Zhao, Longlong Li and Haitian Ma

    Citation: BMC Genomics 2018 19:29

    Published on:

  34. Content type: Research article

    Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers a...

    Authors: Héctor Cordero, Monica F. Brinchmann, Alberto Cuesta and María A. Esteban

    Citation: BMC Genomics 2017 18:939

    Published on:

  35. Content type: Research article

    Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns durin...

    Authors: Hui-Zeng Sun, Kai Shi, Xue-Hui Wu, Ming-Yuan Xue, Zi-Hai Wei, Jian-Xin Liu and Hong-Yun Liu

    Citation: BMC Genomics 2017 18:936

    Published on:

  36. Content type: Research article

    Parthenocarpy is an excellent agronomic trait that enables crops to set fruit in the absence of pollination and fertilization, and therefore to produce seedless fruit. Although parthenocarpy is widely recogniz...

    Authors: Ji Li, Jian Xu, Qin-Wei Guo, Zhe Wu, Ting Zhang, Kai-Jing Zhang, Chun-yan Cheng, Pin-yu Zhu, Qun-Feng Lou and Jin-Feng Chen

    Citation: BMC Genomics 2017 18:896

    Published on:

  37. Content type: Research article

    Shotgun proteomics utilizes a database search strategy to compare detected mass spectra to a library of theoretical spectra derived from reference genome information. As such, the robustness of proteomics resu...

    Authors: J. Michael Proffitt, Jeremy Glenn, Anthony J. Cesnik, Avinash Jadhav, Michael R. Shortreed, Lloyd M. Smith, Kylie Kavanagh, Laura A. Cox and Michael Olivier

    Citation: BMC Genomics 2017 18:877

    Published on:

  38. Content type: Research article

    Skeletal muscle development is closely linked to meat production and its quality. This study is the first to quantify the proteomes and metabolomes of breast muscle in two distinct chicken breeds at embryonic ...

    Authors: Ranran Liu, Hongyang Wang, Jie Liu, Jie Wang, Maiqing Zheng, Xiaodong Tan, Siyuan Xing, Huanxian Cui, Qinghe Li, Guiping Zhao and Jie Wen

    Citation: BMC Genomics 2017 18:816

    Published on:

  39. Content type: Research article

    Haliotis diversicolor is commercially important species. The trochophore and veliger are distinct larval stages in gastropod development. Their development involves complex morphologic...

    Authors: Guilan Di, Xianghui Kong, Xiulian Miao, Yifang Zhang, Miaoqin Huang, Yuting Gu, Weiwei You, Jianxin Zhang and Caihuan Ke

    Citation: BMC Genomics 2017 18:809

    Published on:

  40. Content type: Database

    Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae. As a novel class of antibody, they show many advantages com...

    Authors: Jing Zuo, Jian Li, Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang and Wei Xie

    Citation: BMC Genomics 2017 18:797

    Published on:

  41. Content type: Research article

    Salamanders regenerate their limbs after amputation. However, the molecular mechanism of this unique regeneration remains unclear. In this study, isobaric tags for relative and absolute quantification (iTRAQ) ...

    Authors: Jie Tang, Yuan Yu, Hanxue Zheng, Lu Yin, Mei Sun, Wenjun Wang, Jihong Cui, Wenguang Liu, Xin Xie and Fulin Chen

    Citation: BMC Genomics 2017 18:750

    Published on:

  42. Content type: Research article

    Polyploidy is an important phenomenon in plants because of its roles in agricultural and forestry production as well as in plant tolerance to environmental stresses. Tetraploid black locust (Robinia pseudoacacia ...

    Authors: Qiuxiang Luo, Mu Peng, Xiuli Zhang, Pei Lei, Ximei Ji, Wahsoon Chow, Fanjuan Meng and Guanyu Sun

    Citation: BMC Genomics 2017 18:648

    Published on:

  43. Content type: Research article

    Human hepatitis B virus (HBV) infection is an important public health issue in the Asia-Pacific region and is associated with chronic hepatitis, liver fibrosis, cirrhosis and even liver cancer. However, the un...

    Authors: Fangming Kan, Lei Ye, Tao Yan, Jiaqi Cao, Jianhua Zheng and Wuping Li

    Citation: BMC Genomics 2017 18:641

    Published on:

2017 Journal Metrics

Portable peer review

The editors of BMC Genomics support initiatives that expedite the peer review process and are happy to consider manuscripts that have been reviewed in Peerage of Science. Please indicate in your cover letter if this applies to your manuscript.

Space creator