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  1. More than half of the approximately 500,000 women diagnosed with cervical cancer worldwide each year will die from this disease. Investigation of genes expressed in precancer lesions compared to those expresse...

    Authors: Ashleen Shadeo, Raj Chari, Greg Vatcher, Jennifer Campbell, Kim M Lonergan, Jasenka Matisic, Dirk van Niekerk, Thomas Ehlen, Dianne Miller, Michele Follen, Wan L Lam and Calum MacAulay

    Citation: BMC Genomics 2007 8:142

    Content type: Research article

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  2. Death receptors on the cell surface and the interacting cytosolic molecules, adaptors and initiator caspases, are essential as core components of the extrinsic apoptotic signaling pathway. While the apoptotic ...

    Authors: Kazuhiro Sakamaki, Masami Nozaki, Katsuya Kominami and Yutaka Satou

    Citation: BMC Genomics 2007 8:141

    Content type: Research article

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  3. The development of microarrays permits us to monitor transcriptomes on a genome-wide scale. To validate microarray measurements, quantitative-real time-reverse transcription PCR (Q-RT-PCR) is one of the most r...

    Authors: Li-Jen Su, Ching-Wei Chang, Yu-Chung Wu, Kuang-Chi Chen, Chien-Ju Lin, Shu-Ching Liang, Chi-Hung Lin, Jacqueline Whang-Peng, Shih-Lan Hsu, Chen-Hsin Chen and Chi-Ying F Huang

    Citation: BMC Genomics 2007 8:140

    Content type: Methodology article

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  4. TSEs are a group of fatal neurodegenerative diseases occurring in man and animals. They are caused by prions, alternatively folded forms of the endogenous prion protein, encoded by PRNP. Since differences in the ...

    Authors: Evelyne Lampo, Mario Van Poucke, Karine Hugot, Hélène Hayes, Alex Van Zeveren and Luc J Peelman

    Citation: BMC Genomics 2007 8:138

    Content type: Research article

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  5. The Streptophyta comprises all land plants and six groups of charophycean green algae. The scaly biflagellate Mesostigma viride (Mesostigmatales) and the sarcinoid Chlorokybus atmophyticus (Chlorokybales) represe...

    Authors: Monique Turmel, Christian Otis and Claude Lemieux

    Citation: BMC Genomics 2007 8:137

    Content type: Research article

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  6. Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detai...

    Authors: Taewoo Ryu, Juhyun Jung, Sunjae Lee, Ho Jung Nam, Sun Woo Hong, Jae Wook Yoo, Dong-ki Lee and Doheon Lee

    Citation: BMC Genomics 2007 8:136

    Content type: Database

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  7. EST-PCR markers normally represent specific products from target genes, and are therefore effective tools for genetic analysis. However, because wheat is an allohexaploid plant, PCR products derived from homoe...

    Authors: Goro Ishikawa, Junichi Yonemaru, Mika Saito and Toshiki Nakamura

    Citation: BMC Genomics 2007 8:135

    Content type: Research article

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  8. With the advent of low-cost, high-throughput sequencing, the amount of public domain Expressed Sequence Tag (EST) sequence data available for both model and non-model organism is growing exponentially. While t...

    Authors: Chun Liang, Gang Wang, Lin Liu, Guoli Ji, Lin Fang, Yuansheng Liu, Kikia Carter, Jason S Webb and Jeffrey FD Dean

    Citation: BMC Genomics 2007 8:134

    Content type: Database

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  9. The structurally complex network of minicircles and maxicircles comprising the mitochondrial DNA of kinetoplastids mirrors the complexity of the RNA editing process that is required for faithful expression of ...

    Authors: Sean Thomas, LL Isadora Trejo Martinez, Scott J Westenberger and Nancy R Sturm

    Citation: BMC Genomics 2007 8:133

    Content type: Research article

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  10. Extensive computational and database tools are available to mine genomic and genetic databases for model organisms, but little genomic data is available for many species of ecological or agricultural significa...

    Authors: Kankshita Swaminathan, Kranthi Varala and Matthew E Hudson

    Citation: BMC Genomics 2007 8:132

    Content type: Research article

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  11. Previous studies of individual genes have shown that in a self-enforcing way, dimethylation at histone 3 lysine 9 (dimethyl-H3K9) and DNA methylation cooperate to maintain a repressive mode of inactive genes. ...

    Authors: Jiejun Wu, Shu-Huei Wang, Dustin Potter, Joseph C Liu, Laura T Smith, Yue-Zhong Wu, Tim H-M Huang and Christoph Plass

    Citation: BMC Genomics 2007 8:131

    Content type: Research article

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  12. The pentatricopeptide repeat (PPR) is a degenerate 35 amino acid motif that occurs in multiple tandem copies in members of a recently recognized eukaryotic gene family. Most analyzed eukaryotic genomes contain...

    Authors: Rachel Geddy and Gregory G Brown

    Citation: BMC Genomics 2007 8:130

    Content type: Research article

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  13. Cancer/testis (CT) genes are normally expressed only in germ cells, but can be activated in the cancer state. This unusual property, together with the finding that many CT proteins elicit an antigenic response...

    Authors: Brian J Stevenson, Christian Iseli, Sumir Panji, Monique Zahn-Zabal, Winston Hide, Lloyd J Old, Andrew J Simpson and C Victor Jongeneel

    Citation: BMC Genomics 2007 8:129

    Content type: Research article

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  14. Hybrid genes are candidate risk factors for human tumors by inducing mutation, translocation, inversion, or rearrangement of genes. The occurrence of hybrid genes may also have given rise to new transcripts du...

    Authors: Dae-Soo Kim, Jae-Won Huh and Heui-Soo Kim

    Citation: BMC Genomics 2007 8:128

    Content type: Database

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  15. This study aims to characterize the housekeeping and tissue-specific genes in 15 mouse tissues by using the serial analysis of gene expression (SAGE) strategy which indicates the relative level of expression f...

    Authors: Kouame E Kouadjo, Yuichiro Nishida, Jean F Cadrin-Girard, Mayumi Yoshioka and Jonny St-Amand

    Citation: BMC Genomics 2007 8:127

    Content type: Research article

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  16. Expansion of polyglutamine-encoding CAG trinucleotide repeats has been identified as the pathogenic mutation in nine different genes associated with neurodegenerative disorders. The majority of individuals cli...

    Authors: Stefanie L Butland, Rebecca S Devon, Yong Huang, Carri-Lyn Mead, Alison M Meynert, Scott J Neal, Soo Sen Lee, Anna Wilkinson, George S Yang, Macaire MS Yuen, Michael R Hayden, Robert A Holt, Blair R Leavitt and BF Francis Ouellette

    Citation: BMC Genomics 2007 8:126

    Content type: Research article

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  17. The heat shock response of Arabidopsis thaliana is dependent upon a complex regulatory network involving twenty-one known transcription factors and four heat shock protein families. It is known that heat shock pr...

    Authors: William R Swindell, Marianne Huebner and Andreas P Weber

    Citation: BMC Genomics 2007 8:125

    Content type: Research article

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  18. Toll-like receptors (TLRs) play a central role in innate immunity. TLRs are membrane glycoproteins and contain leucine rich repeat (LRR) motif in the ectodomain. TLRs recognize and respond to molecules such as...

    Authors: Norio Matsushima, Takanori Tanaka, Purevjav Enkhbayar, Tomoko Mikami, Masae Taga, Keiko Yamada and Yoshio Kuroki

    Citation: BMC Genomics 2007 8:124

    Content type: Research article

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  19. Genetic analysis of Escherichia coli O157:H7 strains has shown divergence into two distinct lineages, lineages I and II, that appear to have distinct ecological characteristics, with lineage I strains more common...

    Authors: Yongxiang Zhang, Chad Laing, Marina Steele, Kim Ziebell, Roger Johnson, Andrew K Benson, Eduardo Taboada and Victor PJ Gannon

    Citation: BMC Genomics 2007 8:121

    Content type: Research article

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  20. White spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide. However, little information is ...

    Authors: Jiann-Horng Leu, Chih-Chin Chang, Jin-Lu Wu, Chun-Wei Hsu, Ikuo Hirono, Takashi Aoki, Hsueh-Fen Juan, Chu-Fang Lo, Guang-Hsiung Kou and Hsuan-Cheng Huang

    Citation: BMC Genomics 2007 8:120

    Content type: Research article

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  21. Scorpions like other venomous animals posses a highly specialized organ that produces, secretes and disposes the venom components. In these animals, the last postabdominal segment, named telson, contains a pai...

    Authors: Elisabeth F Schwartz, Elia Diego-Garcia, Ricardo C Rodríguez de la Vega and Lourival D Possani

    Citation: BMC Genomics 2007 8:119

    Content type: Research article

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  22. The western African clawed frog Xenopus tropicalis is an anuran amphibian species now used as model in vertebrate comparative genomics. It provides the same advantages as Xenopus laevis but is diploid and has a s...

    Authors: Ana C Fierro, Raphaël Thuret, Laurent Coen, Muriel Perron, Barbara A Demeneix, Maurice Wegnez, Gabor Gyapay, Jean Weissenbach, Patrick Wincker, André Mazabraud and Nicolas Pollet

    Citation: BMC Genomics 2007 8:118

    Content type: Research article

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  23. Cell lines have been used to study cancer for decades, but truly quantitative assessment of their performance as models is often lacking. We used gene expression profiling to quantitatively assess the gene exp...

    Authors: Mark W Carlson, Vishwanath R Iyer and Edward M Marcotte

    Citation: BMC Genomics 2007 8:117

    Content type: Research article

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  24. Gene knockouts are a critical resource for functional genomics. In Arabidopsis, comprehensive knockout collections were generated by amplifying and sequencing genomic DNA flanking insertion mutants. These Flan...

    Authors: A Mark Settles, David R Holding, Bao Cai Tan, Susan P Latshaw, Juan Liu, Masaharu Suzuki, Li Li, Brent A O'Brien, Diego S Fajardo, Ewa Wroclawska, Chi-Wah Tseung, Jinsheng Lai, Charles T Hunter III, Wayne T Avigne, John Baier, Joachim Messing…

    Citation: BMC Genomics 2007 8:116

    Content type: Research article

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  25. Mimivirus isolated from A. polyphaga is the largest virus discovered so far. It is unique among all the viruses in having genes related to translation, DNA repair and replication which bear close homology to euka...

    Authors: Harpreet Kaur Saini and Daniel Fischer

    Citation: BMC Genomics 2007 8:115

    Content type: Research article

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  26. The outermost layer of the bacterial surface is of crucial importance because it is in constant interaction with the host. Glycopeptidolipids (GPLs) are major surface glycolipids present on various mycobacteri...

    Authors: Fabienne Ripoll, Caroline Deshayes, Sophie Pasek, Françoise Laval, Jean-Luc Beretti, Franck Biet, Jean-Loup Risler, Mamadou Daffé, Gilles Etienne, Jean-Louis Gaillard and Jean-Marc Reyrat

    Citation: BMC Genomics 2007 8:114

    Content type: Research article

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  27. Quantitative phenotypic variation of agronomic characters in crop plants is controlled by environmental and genetic factors (quantitative trait loci = QTL). To understand the molecular basis of such QTL, the i...

    Authors: Agim Ballvora, Anika Jöcker, Prisca Viehöver, Hirofumi Ishihara, Jürgen Paal, Khalid Meksem, Rémy Bruggmann, Heiko Schoof, Bernd Weisshaar and Christiane Gebhardt

    Citation: BMC Genomics 2007 8:112

    Content type: Research article

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  28. Array-based comparative genomic hybridization (aCGH) is a high-throughput method for measuring genome-wide DNA copy number changes. Current aCGH methods have limited resolution, sensitivity and reproducibility...

    Authors: Herbert Auer, David L Newsom, Norma J Nowak, Kirk M McHugh, Sunita Singh, Chack-Yung Yu, Yan Yang, Gail D Wenger, Julie M Gastier-Foster and Karl Kornacker

    Citation: BMC Genomics 2007 8:111

    Content type: Methodology article

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  29. Previous studies have sought to identify a link between the distribution of variable genes amongst isolates of Campylobacter jejuni and particular host preferences. The genomic sequence data available currently w...

    Authors: Philip J Hepworth, Howard Leatherbarrow, C Anthony Hart and Craig Winstanley

    Citation: BMC Genomics 2007 8:110

    Content type: Research article

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  30. As the developmental costs of genomic tools decline, genomic approaches to non-model systems are becoming more feasible. Many of these systems may lack advanced genetic tools but are extremely valuable models ...

    Authors: Patrick D Danley, Sean P Mullen, Fenglong Liu, Vishvanath Nene, John Quackenbush and Kerry L Shaw

    Citation: BMC Genomics 2007 8:109

    Content type: Research article

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  31. The Cation Diffusion Facilitator (CDF) family is a ubiquitous family of heavy metal transporters. Much interest in this family has focused on implications for human health and bioremediation. In this work a br...

    Authors: Barbara Montanini, Damien Blaudez, Sylvain Jeandroz, Dale Sanders and Michel Chalot

    Citation: BMC Genomics 2007 8:107

    Content type: Research article

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  32. We provide a re-analysis of the Golden Spike dataset, a first generation "spike-in" control microarray dataset. The original analysis of the Golden Spike dataset was presented in a manuscript by Choe et al. an...

    Authors: Daniel P Gaile and Jeffrey C Miecznikowski

    Citation: BMC Genomics 2007 8:105

    Content type: Research article

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  33. Comprehensive identification and classification of the transcription factors (TFs) in a given genome is an important aspect in understanding transcriptional regulatory networks of a specific organism. Cyanobac...

    Authors: Jinyu Wu, Fangqing Zhao, Shengqin Wang, Gang Deng, Junrong Wang, Jie Bai, Jianxin Lu, Jia Qu and Qiyu Bao

    Citation: BMC Genomics 2007 8:104

    Content type: Database

    Published on:

  34. The number of completed eukaryotic genome sequences and cDNA projects has increased exponentially in the past few years although most of them have not been published yet. In addition, many microarray analyses ...

    Authors: Florian Odronitz, Marcel Hellkamp and Martin Kollmar

    Citation: BMC Genomics 2007 8:103

    Content type: Database

    Published on:

  35. The salivary glands of hematophagous animals contain a complex cocktail that interferes with the host hemostasis and inflammation pathways, thus increasing feeding success. Fleas represent a relatively recent ...

    Authors: John F Andersen, B Joseph Hinnebusch, David A Lucas, Thomas P Conrads, Timothy D Veenstra, Van M Pham and José MC Ribeiro

    Citation: BMC Genomics 2007 8:102

    Content type: Research article

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  36. Following the publication of our recent article (Kapp et al., BMC Genomics 2006, 7:231), we (the authors) regrettably found several errors in the published Table 5. This correction article not only describes what...

    Authors: Amy V Kapp, Stefanie S Jeffrey, Anita Langerød, Anne-Lise Børresen-Dale, Wonshik Han, Dong-Young Noh, Ida RK Bukholm, Monica Nicolau, Patrick O Brown and Robert Tibshirani

    Citation: BMC Genomics 2007 8:101

    Content type: Erratum

    Published on:

    The original article was published in BMC Genomics 2006 7:231

  37. Conidia are considered to be the primary cause of infections by Trichophyton rubrum.

    Authors: Tao Liu, Qian Zhang, Lingling Wang, Lu Yu, Wenchuan Leng, Jian Yang, Lihong Chen, Junping Peng, Li Ma, Jie Dong, Xingye Xu, Ying Xue, Yafang Zhu, Wenliang Zhang, Li Yang, Weijun Li…

    Citation: BMC Genomics 2007 8:100

    Content type: Research article

    Published on:

  38. Mammalian hepatic lipase (HL) genes are transcribed almost exclusively in hepatocytes. The basis for this liver-restricted expression is not completely understood. We hypothesized that the responsible cis-acti...

    Authors: Diederik van Deursen, Gert-Jan Botma, Hans Jansen and Adrie JM Verhoeven

    Citation: BMC Genomics 2007 8:99

    Content type: Research article

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  39. TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour c...

    Authors: Prathibha Ranganathan, Animesh Agrawal, Raghu Bhushan, Aravinda K Chavalmane, Ravi Kiran Reddy Kalathur, Takashi Takahashi and Paturu Kondaiah

    Citation: BMC Genomics 2007 8:98

    Content type: Research article

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  40. Mycotoxins are fungal secondary metabolites commonly present in feed and food, and are widely regarded as hazardous contaminants. Citrinin, one of the very well known mycotoxins that was first isolated from Penic...

    Authors: Hitoshi Iwahashi, Emiko Kitagawa, Yoshiteru Suzuki, Youji Ueda, Yo-hei Ishizawa, Hitoshi Nobumasa, Yoshihide Kuboki, Hiroshi Hosoda and Yumiko Iwahashi

    Citation: BMC Genomics 2007 8:95

    Content type: Research article

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  41. The mammalian brain is divided into distinct regions with structural and neurophysiological differences. As a result, gene expression is likely to vary between regions in relation to their cellular composition...

    Authors: Christine Stansberg, Audun Osland Vik-Mo, Rita Holdhus, Harald Breilid, Boleslaw Srebro, Kjell Petersen, Hugo A Jørgensen, Inge Jonassen and Vidar M Steen

    Citation: BMC Genomics 2007 8:94

    Content type: Research article

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  42. Insects constitute the vast majority of known species with their importance including biodiversity, agricultural, and human health concerns. It is likely that the successful adaptation of the Insecta clade dep...

    Authors: Guojie Zhang, Hongsheng Wang, Junjie Shi, Xiaoling Wang, Hongkun Zheng, Gane Ka-Shu Wong, Terry Clark, Wen Wang, Jun Wang and Le Kang

    Citation: BMC Genomics 2007 8:93

    Content type: Research article

    Published on:

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