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  1. Mutations in the human polycystic kidney disease-1 (hPKD1) gene result in ~85% of cases of autosomal dominant polycystic kidney disease, the most frequent human monogenic disease. PKD1 proteins are large multidom...

    Authors: H Jayantha Gunaratne, Gary W Moy, Masashi Kinukawa, Shinji Miyata, Silvia A Mah and Victor D Vacquier
    Citation: BMC Genomics 2007 8:235
  2. In situ hybridization (ISH) is a powerful method for visualizing gene expression patterns at the organismal level with cellular resolution. When automated, it is capable of determining the expression of a large n...

    Authors: Murat Cankaya, Ana Martinez Hernandez, Mehmet Ciftci, Sukru Beydemir, Hasan Ozdemir, Harun Budak, Ilhami Gulcin, Veysel Comakli, Tufan Emircupani, Deniz Ekinci, Muslum Kuzu, Qiuhong Jiang, Gregor Eichele and Omer Irfan Kufrevioglu
    Citation: BMC Genomics 2007 8:232
  3. Phylogenetic and functional analysis was conducted on an Anopheles gambiae gene, ENSANGG00000017398. Based on phylogenetic analysis, this gene belongs to the same lineage as Heat shock protein cognate 70-4 (Hsc70...

    Authors: Cheolho Sim, Young S Hong, Konstantin A Tsetsarkin, Dana L Vanlandingham, Stephen Higgs and Frank H Collins
    Citation: BMC Genomics 2007 8:231
  4. Human natural killer (NK) cells are the key contributors of innate immune response and the effector functions of these cells are enhanced by cytokines such as interleukine 2 (IL2). We utilized genome-wide tran...

    Authors: Karen Dybkaer, Javeed Iqbal, Guimei Zhou, Huimin Geng, Li Xiao, Alexander Schmitz, Francesco d'Amore and Wing C Chan
    Citation: BMC Genomics 2007 8:230
  5. The genomes of Streptomyces coelicolor and Streptomyces lividans bear a considerable degree of synteny. While S. coelicolor is the model streptomycete for studying antibiotic synthesis and differentiation, S. liv...

    Authors: Karthik P Jayapal, Wei Lian, Frank Glod, David H Sherman and Wei-Shou Hu
    Citation: BMC Genomics 2007 8:229
  6. Fabaceae (legumes) is one of the largest families of flowering plants, and some members are important crops. In contrast to what we know about their great diversity or economic importance, our knowledge at the...

    Authors: Xianwu Guo, Santiago Castillo-Ramírez, Víctor González, Patricia Bustos, José Luís Fernández-Vázquez, Rosa Isela Santamaría, Jesús Arellano, Miguel A Cevallos and Guillermo Dávila
    Citation: BMC Genomics 2007 8:228
  7. Voltage-gated Na+ channel β1 (Scn1b) subunits are multi-functional proteins that play roles in current modulation, channel cell surface expression, cell adhesion, cell migration, and neurite outgrowth. We have sh...

    Authors: Amanda J Fein, Laurence S Meadows, Chunling Chen, Emily A Slat and Lori L Isom
    Citation: BMC Genomics 2007 8:226
  8. Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with ...

    Authors: Caroline Tapparel, Thomas Junier, Daniel Gerlach, Samuel Cordey, Sandra Van Belle, Luc Perrin, Evgeny M Zdobnov and Laurent Kaiser
    Citation: BMC Genomics 2007 8:224
  9. The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in...

    Authors: Ana M González, José M Larruga, Khaled K Abu-Amero, Yufei Shi, José Pestano and Vicente M Cabrera
    Citation: BMC Genomics 2007 8:223
  10. Post-puberty deterioration of kidneys is more rapid in males than in females. To reveal the underlying molecular mechanisms for this difference, we analyzed gender-dependent gene expression in kidneys of three...

    Authors: Li Li, Susanne N Boehn, Xiaolei Yu, Qingqin Zhang, Marc Kenzelmann, Dieter Techel, Salah A Mohamed, Petra Jakob, Bettina Kraenzlin, Sigrid Hoffmann and Norbert Gretz
    Citation: BMC Genomics 2007 8:221
  11. Bordetella bronchiseptica is a bacterial respiratory pathogen that infects a broad range of mammals, causing chronic and often subclinical infections. Gene expression in Bordetella is regulated by a two-component...

    Authors: Tracy L Nicholson
    Citation: BMC Genomics 2007 8:220
  12. Three kinases: Sch9, PKA and TOR, are suggested to be involved in both the replicative and chronological ageing in yeast. They function in pathways whose down-regulation leads to life span extension. Several s...

    Authors: Chao Cheng, Paola Fabrizio, Huanying Ge, Valter D Longo and Lei M Li
    Citation: BMC Genomics 2007 8:219
  13. Functional and comparative studies of insect genomes have shed light on the complement of genes, which in part, account for shared morphologies, developmental programs and life-histories. Contrasting the gene ...

    Authors: John K Colbourne, Brian D Eads, Joseph Shaw, Elizabeth Bohuski, Darren J Bauer and Justen Andrews
    Citation: BMC Genomics 2007 8:217
  14. To gain insight into host-microbe interactions in a piglet model, a functional genomics approach was used to address the working hypothesis that transcriptionally regulated genes associated with promoting epit...

    Authors: Shankar R Chowdhury, Dale E King, Benjamin P Willing, Mark R Band, Jonathan E Beever, Adrienne B Lane, Juan J Loor, Juan C Marini, Laurie A Rund, Lawrence B Schook, Andrew G Van Kessel and H Rex Gaskins
    Citation: BMC Genomics 2007 8:215
  15. Genetic influences underpinning complex traits are thought to involve multiple quantitative trait loci (QTLs) of small effect size. Detection of such QTL associations requires systematic screening of large num...

    Authors: Sophia J Docherty, Lee M Butcher, Leonard C Schalkwyk and Robert Plomin
    Citation: BMC Genomics 2007 8:214
  16. In the Chlorophyta – the green algal phylum comprising the classes Prasinophyceae, Ulvophyceae, Trebouxiophyceae and Chlorophyceae – the chloroplast genome displays a highly variable architecture. While chloro...

    Authors: Jean-Charles de Cambiaire, Christian Otis, Monique Turmel and Claude Lemieux
    Citation: BMC Genomics 2007 8:213
  17. Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS) is a tool that can be used to accelerate the development of no...

    Authors: David Chagné, Charmaine M Carlisle, Céline Blond, Richard K Volz, Claire J Whitworth, Nnadozie C Oraguzie, Ross N Crowhurst, Andrew C Allan, Richard V Espley, Roger P Hellens and Susan E Gardiner
    Citation: BMC Genomics 2007 8:212
  18. The recent discovery of widespread copy number variation in humans has forced a shift away from the assumption of two copies per locus per cell throughout the autosomal genome. In particular, a SNP site can no...

    Authors: Laura E MacConaill, Micheala A Aldred, Xincheng Lu and Thomas LaFramboise
    Citation: BMC Genomics 2007 8:211
  19. The pluripotency and self-renewal capabilities, which define the "stemness" state, of mouse embryonic stem (ES) cells, are usually investigated by functional assays or quantitative measurements of the expressi...

    Authors: Daniel YL Yap, David K Smith, Xue W Zhang and Jeffrey Hill
    Citation: BMC Genomics 2007 8:210
  20. To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their relevant sequences...

    Authors: Alexei A Adzhubei, Anna V Vlasova, Heidi Hagen-Larsen, Torgeir A Ruden, Jon K Laerdahl and Bjørn Høyheim
    Citation: BMC Genomics 2007 8:209
  21. Osteoporosis is frequently observed among aging hens from egg-producing strains (layers) of domestic chicken. White Leghorn (WL) has been intensively selected for egg production and it manifests striking pheno...

    Authors: Carl-Johan Rubin, Johan Lindberg, Carolyn Fitzsimmons, Peter Savolainen, Per Jensen, Joakim Lundeberg, Leif Andersson and Andreas Kindmark
    Citation: BMC Genomics 2007 8:208
  22. The liver is the largest human internal organ – it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining homeostasis. Of these cell types the hepato...

    Authors: Jian Huang, Pei Hao, Yun-Li Zhang, Fu-Xing Deng, Qing Deng, Yi Hong, Xiao-Wo Wang, Yun Wang, Ting-Ting Li, Xue-Gong Zhang, Yi-Xue Li, Peng-Yuan Yang, Hong-Yang Wang and Ze-Guang Han
    Citation: BMC Genomics 2007 8:207
  23. Changes in genomic copy number occur in many human diseases including cancer. Characterization of these changes is important for both basic understanding and diagnosis of these diseases. Microarrays have recen...

    Authors: Kyoko Iwao-Koizumi, Kazunori Maekawa, Yohko Nakamura, Sakae Saito, Shoko Kawamoto, Akira Nakagawara and Kikuya Kato
    Citation: BMC Genomics 2007 8:206
  24. Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation in children and adoles...

    Authors: Claudine G James, Veronica Ulici, Jan Tuckermann, T Michael Underhill and Frank Beier
    Citation: BMC Genomics 2007 8:205
  25. Leptospirosis is a world-widely distributed zoonosis. Humans become infected via exposure to pathogenic Leptospira spp. from contaminated water or soil. The availability of genomic sequences of Leptospira interro...

    Authors: Ping He, Yue-Ying Sheng, Yao-Zhou Shi, Xiu-Gao Jiang, Jin-Hong Qin, Zhi-Ming Zhang, Guo-Ping Zhao and Xiao-Kui Guo
    Citation: BMC Genomics 2007 8:204
  26. Honey bees are known for several striking social behaviors, including a complex pattern of behavioral maturation that gives rise to an age-related colony division of labor and a symbolic dance language, by whi...

    Authors: Moushumi Sen Sarma, Charles W Whitfield and Gene E Robinson
    Citation: BMC Genomics 2007 8:202
  27. The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved funct...

    Authors: Sergey Yaklichkin, Alexander Vekker, Steven Stayrook, Mitchell Lewis and Daniel S Kessler
    Citation: BMC Genomics 2007 8:201
  28. In the post-genomic era, comprehension of cellular processes and systems requires global and non-targeted approaches to handle vast amounts of biological information.

    Authors: Hirokazu Kobayashi, Joe Akitomi, Nobuyuki Fujii, Kazuo Kobayashi, Md Altaf-Ul-Amin, Ken Kurokawa, Naotake Ogasawara and Shigehiko Kanaya
    Citation: BMC Genomics 2007 8:197
  29. Bulked segregant analysis (BSA) identifies molecular markers associated with a phenotype by screening two DNA pools of phenotypically distinct plants for markers with skewed allele frequencies. In contrast to ...

    Authors: Peter Wenzl, Harsh Raman, Junping Wang, Meixue Zhou, Eric Huttner and Andrzej Kilian
    Citation: BMC Genomics 2007 8:196
  30. The zebrafish (Danio rerio) is an important vertebrate model organism system for biomedical research. The syntenic conservation between the zebrafish and human genome allows one to investigate the function of hum...

    Authors: Jennifer L Freeman, Adeola Adeniyi, Ruby Banerjee, Stephanie Dallaire, Sean F Maguire, Jianxiang Chi, Bee Ling Ng, Cinthya Zepeda, Carol E Scott, Sean Humphray, Jane Rogers, Yi Zhou, Leonard I Zon, Nigel P Carter, Fengtang Yang and Charles Lee
    Citation: BMC Genomics 2007 8:195
  31. Mammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, ha...

    Authors: Monika Rella, Joann L Elliot, Timothy J Revett, Jerry Lanfear, Anne Phelan, Richard M Jackson, Anthony J Turner and Nigel M Hooper
    Citation: BMC Genomics 2007 8:194
  32. Excessive accumulation of lipids in the adipose tissue is a major problem in the present-day broiler industry. However, few studies have analyzed the expression of adipose tissue genes that are involved in pat...

    Authors: Hong-Bao Wang, Hui Li, Qi-Gui Wang, Xin-Yu Zhang, Shou-Zhi Wang, Yu-Xiang Wang and Xiu-Ping Wang
    Citation: BMC Genomics 2007 8:193
  33. This study assesses the whole-genome gene expression changes in a panel of primary human cell lines in response to DNA damage mediated by decay of DNA-incorporated radioiodinated thymidine analog 5-[125I]iodo-2'-...

    Authors: Mykyta V Sokolov, Ronald D Neumann and Igor G Panyutin
    Citation: BMC Genomics 2007 8:192
  34. The carboxy termini of proteins are a frequent site of activity for a variety of biologically important functions, ranging from post-translational modification to protein targeting. Several short peptide motif...

    Authors: Ryan S Austin, Nicholas J Provart and Sean R Cutler
    Citation: BMC Genomics 2007 8:191
  35. The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug developm...

    Authors: Nicole A Datson, Maarten C Morsink, Srebrena Atanasova, Victor W Armstrong, Hans Zischler, Christina Schlumbohm, Bas E Dutilh, Martijn A Huynen, Brigitte Waegele, Andreas Ruepp, E Ronald de Kloet and Eberhard Fuchs
    Citation: BMC Genomics 2007 8:190
  36. Cholangiocarcinoma (CCA) – cancer of the bile ducts – is associated with chronic infection with the liver fluke, Opisthorchis viverrini. Despite being the only eukaryote that is designated as a 'class I carcinoge...

    Authors: Thewarach Laha, Porntip Pinlaor, Jason Mulvenna, Banchob Sripa, Manop Sripa, Michael J Smout, Robin B Gasser, Paul J Brindley and Alex Loukas
    Citation: BMC Genomics 2007 8:189
  37. Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE into clinical practice of leukemi...

    Authors: Marta Campo Dell'Orto, Andrea Zangrando, Luca Trentin, Rui Li, Wei-min Liu, Geertruy te Kronnie, Giuseppe Basso and Alexander Kohlmann
    Citation: BMC Genomics 2007 8:188
  38. Berries of grape (Vitis vinifera) contain three major tissue types (skin, pulp and seed) all of which contribute to the aroma, color, and flavor characters of wine. The pericarp, which is composed of the exocarp ...

    Authors: Jerome Grimplet, Laurent G Deluc, Richard L Tillett, Matthew D Wheatley, Karen A Schlauch, Grant R Cramer and John C Cushman
    Citation: BMC Genomics 2007 8:187
  39. Five species of the genus Schistosoma, a parasitic trematode flatworm, are causative agents of Schistosomiasis, a disease that is endemic in a large number of developing countries, affecting millions of patien...

    Authors: Elida PB Ojopi, Paulo SL Oliveira, Diana N Nunes, Apuã Paquola, Ricardo DeMarco, Sheila P Gregório, Karina A Aires, Carlos FM Menck, Luciana CC Leite, Sergio Verjovski-Almeida and Emmanuel Dias-Neto
    Citation: BMC Genomics 2007 8:186
  40. Many studies have found segregating quantitative trait loci (QTL) for milk production traits in different dairy cattle populations. However, even for relatively large effects with a saturated marker map the co...

    Authors: Micha Ron, Galit Israeli, Eyal Seroussi, Joel I Weller, Jeffrey P Gregg, Moshe Shani and Juan F Medrano
    Citation: BMC Genomics 2007 8:183
  41. The parasitic trematode Schistosoma mansoni is one of the major causative agents of Schistosomiasis, a disease that affects approximately 200 million people, mostly in developing countries. Since much of the path...

    Authors: Michael Waisberg, Francisco P Lobo, Gustavo C Cerqueira, Liana KJ Passos, Omar S Carvalho, Glória R Franco and Najib M El-Sayed
    Citation: BMC Genomics 2007 8:181

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