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  1. MicroRNAs (miRNAs) are a large group of RNAs that play important roles in regulating gene expression and protein translation. Several studies have indicated that some miRNAs are specifically expressed in human...

    Authors: You-Jia Hua, Zhong-Yi Tang, Kang Tu, Li Zhu, Yi-Xue Li, Lu Xie and Hua-Sheng Xiao
    Citation: BMC Genomics 2009 10:214
  2. Germ cells must progress through elaborate developmental stages from an undifferentiated germ cell to a fully differentiated gamete. Some of these stages include exiting mitosis and entering meiosis, progressi...

    Authors: Xin Wang, Yongjun Zhao, Kim Wong, Peter Ehlers, Yuji Kohara, Steven J Jones, Marco A Marra, Robert A Holt, Donald G Moerman and Dave Hansen
    Citation: BMC Genomics 2009 10:213
  3. Water deficit has significant effects on grape berry composition resulting in improved wine quality by the enhancement of color, flavors, or aromas. While some pathways or enzymes affected by water deficit hav...

    Authors: Laurent G Deluc, David R Quilici, Alain Decendit, Jérôme Grimplet, Matthew D Wheatley, Karen A Schlauch, Jean-Michel Mérillon, John C Cushman and Grant R Cramer
    Citation: BMC Genomics 2009 10:212
  4. Whole genome radiation hybrid (WG-RH) maps serve as "scaffolds" to significantly improve the orientation of small bacterial artificial chromosome (BAC) contigs, order genes within the contigs and assist assemb...

    Authors: Jian-Gang Ma, Hiroshi Yasue, Katie E Eyer, Hideki Hiraiwa, Takeshi Shimogiri, Stacey N Meyers, Jonathan E Beever, Lawrence B Schook, Craig W Beattie and Wan-Sheng Liu
    Citation: BMC Genomics 2009 10:211
  5. The availability of whole-genome sequences allows for the identification of the entire set of protein coding genes as well as their regulatory regions. This can be accomplished using multiple complementary met...

    Authors: Alan L Kwan, Linya Li, David C Kulp, Susan K Dutcher and Gary D Stormo
    Citation: BMC Genomics 2009 10:210
  6. African animal trypanosomiasis (AAT) caused by tsetse fly-transmitted protozoa of the genus Trypanosoma is a major constraint on livestock and agricultural production in Africa and is among the top ten global cat...

    Authors: Grace M O'Gorman, Stephen DE Park, Emmeline W Hill, Kieran G Meade, Paul M Coussens, Morris Agaba, Jan Naessens, Stephen J Kemp and David E MacHugh
    Citation: BMC Genomics 2009 10:207
  7. Insect ovarioles are classified into two categories: panoistic and meroistic, the later having apparently evolved from an ancestral panoistic type. Molecular data on oogenesis is practically restricted to mero...

    Authors: Paula Irles, Xavier Bellés and M Dolors Piulachs
    Citation: BMC Genomics 2009 10:206
  8. The entomopathogenic nematode Heterorhabditis bacteriophora and its symbiotic bacterium, Photorhabdus luminescens, are important biological control agents of insect pests. This nematode-bacterium-insect associati...

    Authors: Xiaodong Bai, Byron J Adams, Todd A Ciche, Sandra Clifton, Randy Gaugler, Saskia A Hogenhout, John Spieth, Paul W Sternberg, Richard K Wilson and Parwinder S Grewal
    Citation: BMC Genomics 2009 10:205
  9. MicroRNAs (miRNAs), short ~21-nucleotide RNA molecules, play an important role in post-transcriptional regulation of gene expression. The number of known miRNA hairpins registered in the miRBase database is ra...

    Authors: Ate van der Burgt, Mark WJE Fiers, Jan-Peter Nap and Roeland CHJ van Ham
    Citation: BMC Genomics 2009 10:204
  10. Next-generation sequencing technologies have been applied most often to model organisms or species closely related to a model. However, these methods have the potential to be valuable in many wild organisms, i...

    Authors: Matthew C Hale, Cory R McCormick, James R Jackson and J Andrew DeWoody
    Citation: BMC Genomics 2009 10:203
  11. The wide use of organophosphorus (OP) pesticides makes them an important public health concern. Persistent effects of exposure and the mechanism of neuronal degeneration are continuing issues in OP toxicology....

    Authors: John A Lewis, Maria Szilagyi, Elizabeth Gehman, William E Dennis and David A Jackson
    Citation: BMC Genomics 2009 10:202
  12. We have reported that doxycycline-induced over-expression of wild type prion protein (PrP) in skeletal muscles of Tg(HQK) mice is sufficient to cause a primary myopathy with no signs of peripheral neuropathy. ...

    Authors: Jingjing Liang, Debra Parchaliuk, Sarah Medina, Garrett Sorensen, Laura Landry, Shenghai Huang, Meiling Wang, Qingzhong Kong and Stephanie A Booth
    Citation: BMC Genomics 2009 10:201
  13. In Arabidopsis thaliana (L.) Heynh and Oryza sativa L., a large number of genes encode proteins of unknown functions, whose characterization still remains one of the major challenges. With an aim to characterize ...

    Authors: Hemant R Kushwaha, Anil K Singh, Sudhir K Sopory, Sneh L Singla-Pareek and Ashwani Pareek
    Citation: BMC Genomics 2009 10:200
  14. Interstitial cystitis (IC), a chronic bladder disease with an increasing incidence, is diagnosed using subjective symptoms in combination with cystoscopic and histological evidence. By cystoscopic examination,...

    Authors: Marianne Gamper, Volker Viereck, Verena Geissbühler, Jakob Eberhard, Jochen Binder, Carlo Moll, Hubert Rehrauer and René Moser
    Citation: BMC Genomics 2009 10:199
  15. The increasing number of completely sequenced bacterial genomes allows comparing their architecture and genetic makeup. Such new information highlights the crucial role of lateral genetic exchanges in bacteria...

    Authors: Alexandre Panchaud, Lionel Guy, François Collyn, Marisa Haenni, Masanobu Nakata, Andreas Podbielski, Philippe Moreillon and Claude-Alain H Roten
    Citation: BMC Genomics 2009 10:198
  16. Functional profiling methods have been extensively used in the context of high-throughput experiments and, in particular, in microarray data analysis. Such methods use available biological information to defin...

    Authors: David Montaner, Pablo Minguez, Fátima Al-Shahrour and Joaquín Dopazo
    Citation: BMC Genomics 2009 10:197
  17. Myostatin (MSTN), a member of the TGF-β superfamily, has been identified as a negative regulator of skeletal muscle mass. Inactivating mutations in the MSTN gene are responsible for the development of a hyperm...

    Authors: Ilham Chelh, Bruno Meunier, Brigitte Picard, Mark James Reecy, Catherine Chevalier, Jean-François Hocquette and Isabelle Cassar-Malek
    Citation: BMC Genomics 2009 10:196
  18. MicroRNAs (miRNAs) are a new class of small RNAs of approximately 22 nucleotides in length that control eukaryotic gene expression by fine tuning mRNA translation. They regulate a wide variety of biological pr...

    Authors: Ana R Soares, Patrícia M Pereira, Bruno Santos, Conceição Egas, Ana C Gomes, Joel Arrais, José L Oliveira, Gabriela R Moura and Manuel AS Santos
    Citation: BMC Genomics 2009 10:195
  19. The draft genome sequence of cattle (Bos taurus) has now been analyzed by the Bovine Genome Sequencing and Analysis Consortium and the Bovine HapMap Consortium, which together represent an extensive collaboration...

    Authors: Ross L Tellam, Danielle G Lemay, Curtis P Van Tassell, Harris A Lewin, Kim C Worley and Christine G Elsik
    Citation: BMC Genomics 2009 10:193
  20. WC1 co-receptors are group B scavenger receptor cysteine-rich molecules that are found exclusively on γδT cells and are thought to be encoded by a multi-gene family. Previous studies have shown γδT cells that ...

    Authors: Carolyn TA Herzig and Cynthia L Baldwin
    Citation: BMC Genomics 2009 10:191
  21. Successful reprogramming of a somatic genome to produce a healthy clone by somatic cells nuclear transfer (SCNT) is a rare event and the mechanisms involved in this process are poorly defined. When serial or s...

    Authors: Nelida Rodriguez-Osorio, Zhongde Wang, Poothappillai Kasinathan, Grier P Page, James M Robl and Erdogan Memili
    Citation: BMC Genomics 2009 10:190
  22. Bidirectional promoters are shared regulatory regions that influence the expression of two oppositely oriented genes. This type of regulatory architecture is found more frequently than expected by chance in th...

    Authors: Helen Piontkivska, Mary Q Yang, Denis M Larkin, Harris A Lewin, James Reecy and Laura Elnitski
    Citation: BMC Genomics 2009 10:189
  23. Detailed information regarding the number and organization of transfer RNA (tRNA) genes at the genome level is becoming readily available with the increase of DNA sequencing of whole genomes. However the ident...

    Authors: Dave TP Tang, Evgeny A Glazov, Sean M McWilliam, Wesley C Barris and Brian P Dalrymple
    Citation: BMC Genomics 2009 10:188
  24. Linkage analyses strongly suggest a number of QTL for production, health and conformation traits in the middle part of bovine chromosome 6 (BTA6). The identification of the molecular background underlying the ...

    Authors: Rosemarie Weikard, Tom Goldammer, Annett Eberlein and Christa Kuehn
    Citation: BMC Genomics 2009 10:186
  25. The Pregnancy-associated glycoproteins (PAGs) belong to a large family of aspartic peptidases expressed exclusively in the placenta of species in the Artiodactyla order. In cattle, the PAG gene family is comprise...

    Authors: Bhanu Prakash VL Telugu, Angela M Walker and Jonathan A Green
    Citation: BMC Genomics 2009 10:185
  26. Embryonic genome activation (EGA) is a critical event for the preimplantation embryo, which is manifested by changes in chromatin structure, transcriptional machinery, expression of embryonic genes, and degrad...

    Authors: Alper Uzun, Nelida Rodriguez-Osorio, Abdullah Kaya, Hongfeng Wang, John J Parrish, Valentin A Ilyin and Erdogan Memili
    Citation: BMC Genomics 2009 10:183
  27. The cattle MHC is termed the bovine leukocyte antigen (BoLA) and, along with the MHCs of other ruminants, is unique in its genomic organization. Consequently, correct and reliable gene maps and sequence inform...

    Authors: Candice L Brinkmeyer-Langford, Christopher P Childers, Krista L Fritz, Ashley L Gustafson-Seabury, Marian Cothran, Terje Raudsepp, James E Womack and Loren C Skow
    Citation: BMC Genomics 2009 10:182
  28. Identifying recent positive selection signatures in domesticated animals could provide information on genome response to strong directional selection from domestication and artificial selection. With the compl...

    Authors: Sean MacEachern, Ben Hayes, John McEwan and Mike Goddard
    Citation: BMC Genomics 2009 10:181
  29. We present here the assembly of the bovine genome. The assembly method combines the BAC plus WGS local assembly used for the rat and sea urchin with the whole genome shotgun (WGS) only assembly used for many o...

    Authors: Yue Liu, Xiang Qin, Xing-Zhi Henry Song, Huaiyang Jiang, Yufeng Shen, K James Durbin, Sigbjørn Lien, Matthew Peter Kent, Marte Sodeland, Yanru Ren, Lan Zhang, Erica Sodergren, Paul Havlak, Kim C Worley, George M Weinstock and Richard A Gibbs
    Citation: BMC Genomics 2009 10:180
  30. If mutation within the coding region of the genome is largely not adaptive, the ratio of nonsynonymous (dN) to synonymous substitutions (dS) per site (dN/dS) should be approximately equal among closely related...

    Authors: Sean MacEachern, John McEwan, Alan McCulloch, Andrew Mather, Keith Savin and Mike Goddard
    Citation: BMC Genomics 2009 10:179
  31. The goal of genome wide analyses of polymorphisms is to achieve a better understanding of the link between genotype and phenotype. Part of that goal is to understand the selective forces that have operated on ...

    Authors: William Barendse, Blair E Harrison, Rowan J Bunch, Merle B Thomas and Lex B Turner
    Citation: BMC Genomics 2009 10:178
  32. The Bovinae subfamily incorporates an array of antelope, buffalo and cattle species. All of the members of this subfamily have diverged recently. Not surprisingly, a number of phylogenetic studies from molecul...

    Authors: Sean MacEachern, John McEwan and Mike Goddard
    Citation: BMC Genomics 2009 10:177
  33. Fertility is one of the most critical factors controlling biological and financial performance of animal production systems and genetic improvement of lines. The objective of this study was to identify molecul...

    Authors: Jean M Feugang, Abdullah Kaya, Grier P Page, Lang Chen, Tapan Mehta, Kashif Hirani, Lynne Nazareth, Einko Topper, Richard Gibbs and Erdogan Memili
    Citation: BMC Genomics 2009 10:176
  34. Branchiopod crustaceans in the genus Daphnia are key model organisms for investigating interactions between genes and the environment. One major theme of research on Daphnia species has been the evolution of resi...

    Authors: Seanna J McTaggart, Claire Conlon, John K Colbourne, Mark L Blaxter and Tom J Little
    Citation: BMC Genomics 2009 10:175
  35. EST sequencing projects are increasing in scale and scope as the genome sequencing technologies migrate from core sequencing centers to individual research laboratories. Effectively, generating EST data is no ...

    Authors: Zuojian Tang, Jeong-Hyeon Choi, Chris Hemmerich, Ankita Sarangi, John K Colbourne and Qunfeng Dong
    Citation: BMC Genomics 2009 10:174
  36. Shotgun sequences of DNA extracts from whole organisms allow a comprehensive assessment of possible symbionts. The current project makes use of four shotgun datasets from three species of the planktonic freshw...

    Authors: Weihong Qi, Guang Nong, James F Preston, Frida Ben-Ami and Dieter Ebert
    Citation: BMC Genomics 2009 10:172
  37. Daphniids, commonly known as waterfleas, serve as important model systems for ecology, evolution and the environmental sciences. The sequencing and annotation of the Daphnia pulex genome both open future avenues ...

    Authors: Thomas Fröhlich, Georg J Arnold, Rainer Fritsch, Tobias Mayr and Christian Laforsch
    Citation: BMC Genomics 2009 10:171
  38. The large gene superfamily of ABC (ATP-binding cassette) transporters encodes membrane proteins involved in trafficking processes across biological membranes and further essential cell biological functions. AB...

    Authors: Armin Sturm, Phil Cunningham and Michael Dean
    Citation: BMC Genomics 2009 10:170
  39. Cytochrome P450s (CYPs) in animals fall into two categories: those that synthesize or metabolize endogenous molecules and those that interact with exogenous chemicals from the diet or the environment. The latt...

    Authors: William S Baldwin, Peter B Marko and David R Nelson
    Citation: BMC Genomics 2009 10:169
  40. The unique properties of wheat flour primarily depend on gluten, which is the most important source of protein for human being. γ-Gliadins have been considered to be the most ancient of the wheat gluten family...

    Authors: Peng-Fei Qi, Yu-Ming Wei, Thérèse Ouellet, Qing Chen, Xin Tan and You-Liang Zheng
    Citation: BMC Genomics 2009 10:168
  41. The phylogenetic position of Bryozoa is one of the most controversial issues in metazoan phylogeny. In an attempt to address this issue, the first bryozoan mitochondrial genome from Flustrellidra hispida (Gymnola...

    Authors: Kuem Hee Jang and Ui Wook Hwang
    Citation: BMC Genomics 2009 10:167
  42. To determine level, variability and functional annotation of gene expression of the human retinal pigment epithelium (RPE), the key tissue involved in retinal diseases like age-related macular degeneration and...

    Authors: Judith C Booij, Simone van Soest, Sigrid MA Swagemakers, Anke HW Essing, Annemieke JMH Verkerk, Peter J van der Spek, Theo GMF Gorgels and Arthur AB Bergen
    Citation: BMC Genomics 2009 10:164

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