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  1. Iron (Fe) is an essential nutrient in plants and animals, and Fe deficiency results in decreased vitality and performance. Due to limited bio-availability of Fe, plants have evolved sophisticated adaptive alte...

    Authors: Thomas J Buckhout, Thomas JW Yang and Wolfgang Schmidt
    Citation: BMC Genomics 2009 10:147
  2. Previous work from our laboratory showed that (i) vertebrate genomes are mosaics of isochores, typically megabase-size DNA segments that are fairly homogeneous in base composition; (ii) isochores belong to a s...

    Authors: Maria Costantini, Rosalia Cammarano and Giorgio Bernardi
    Citation: BMC Genomics 2009 10:146
  3. Staphylothermus marinus is an anaerobic, sulfur-reducing peptide fermenter of the archaeal phylum Crenarchaeota. It is the third heterotrophic, obligate sulfur reducing crenarchaeote to be sequenced and provides ...

    Authors: Iain J Anderson, Lakshmi Dharmarajan, Jason Rodriguez, Sean Hooper, Iris Porat, Luke E Ulrich, James G Elkins, Kostas Mavromatis, Hui Sun, Miriam Land, Alla Lapidus, Susan Lucas, Kerrie Barry, Harald Huber, Igor B Zhulin, William B Whitman…
    Citation: BMC Genomics 2009 10:145
  4. In mammals, imprinted genes are regulated by an epigenetic mechanism that results in parental origin-specific expression. Though allele-specific regulation of imprinted genes has been studied for several indiv...

    Authors: Christine Steinhoff, Martina Paulsen, Szymon Kielbasa, Jörn Walter and Martin Vingron
    Citation: BMC Genomics 2009 10:144
  5. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) has recently been used to identify the modification patterns for the methylation and acetylation of many different histone tails ...

    Authors: Jeffrey A Rosenfeld, Zhibin Wang, Dustin E Schones, Keji Zhao, Rob DeSalle and Michael Q Zhang
    Citation: BMC Genomics 2009 10:143
  6. Transcriptional networks coordinate adipocyte differentiation and energy metabolism in rodents. The level of fiber and starch in diets with adequate energy content fed to young cattle has the potential to alte...

    Authors: Daniel E Graugnard, Paola Piantoni, Massimo Bionaz, Larry L Berger, Dan B Faulkner and Juan J Loor
    Citation: BMC Genomics 2009 10:142
  7. In oviparous vertebrates, including fish, vitellogenesis consists of highly regulated pathways involving 17β-estradiol (E2). Previous studies focused on a relatively small number of hepatic expressed genes dur...

    Authors: Liraz Levi, Irena Pekarski, Ellen Gutman, Paolo Fortina, Terry Hyslop, Jakob Biran, Berta Levavi-Sivan and Esther Lubzens
    Citation: BMC Genomics 2009 10:141
  8. Completely sequenced plant genomes provide scope for designing a large number of microsatellite markers, which are useful in various aspects of crop breeding and genetic analysis. With the objective of develop...

    Authors: Swarup Kumar Parida, Vivek Dalal, Ashok Kumar Singh, Nagendra Kumar Singh and Trilochan Mohapatra
    Citation: BMC Genomics 2009 10:140
  9. It has been demonstrated that a reliable and fail-safe sequencing strategy is mandatory for high-quality analysis of mitochondrial (mt) DNA, as the sequencing and base-calling process is prone to error. Here, ...

    Authors: Liane Fendt, Bettina Zimmermann, Martin Daniaux and Walther Parson
    Citation: BMC Genomics 2009 10:139
  10. Down syndrome is a chromosomal disorder caused by the presence of three copies of chromosome 21. The mechanisms by which this aneuploidy produces the complex and variable phenotype observed in people with Down...

    Authors: Julien Laffaire, Isabelle Rivals, Luce Dauphinot, Fabien Pasteau, Rosine Wehrle, Benoit Larrat, Tania Vitalis, Randal X Moldrich, Jean Rossier, Ralph Sinkus, Yann Herault, Isabelle Dusart and Marie-Claude Potier
    Citation: BMC Genomics 2009 10:138
  11. The cell cycle machinery interprets oncogenic signals and reflects the biology of cancers. To date, various methods for cell cycle phase estimation such as mitotic index, S phase fraction, and immunohistochemi...

    Authors: Hideaki Mizuno, Yoshito Nakanishi, Nobuya Ishii, Akinori Sarai and Kunio Kitada
    Citation: BMC Genomics 2009 10:137
  12. There are many advantages to the application of complete mitochondrial (mt) genomes in the accurate reconstruction of phylogenetic relationships in Metazoa. Although over one thousand metazoan genomes have bee...

    Authors: Xin Shen, Xiaoyin Ma, Jianfeng Ren and Fangqing Zhao
    Citation: BMC Genomics 2009 10:136
  13. Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response ...

    Authors: Paolo Uva, Luigi Aurisicchio, James Watters, Andrey Loboda, Amit Kulkarni, John Castle, Fabio Palombo, Valentina Viti, Giuseppe Mesiti, Valentina Zappulli, Laura Marconato, Francesca Abramo, Gennaro Ciliberto, Armin Lahm, Nicola La Monica and Emanuele de Rinaldis
    Citation: BMC Genomics 2009 10:135
  14. Genetic linkage maps are necessary for mapping of mendelian traits and quantitative trait loci (QTLs). To identify the actual genes, which control these traits, a map based on gene-associated single nucleotide...

    Authors: Rikke KK Vingborg, Vivi R Gregersen, Bujie Zhan, Frank Panitz, Anette Høj, Kirsten K Sørensen, Lone B Madsen, Knud Larsen, Henrik Hornshøj, Xuefei Wang and Christian Bendixen
    Citation: BMC Genomics 2009 10:134
  15. Iron homeostasis of Shewanella oneidensis, a γ-proteobacterium possessing high iron content, is regulated by a global transcription factor Fur. However, knowledge is incomplete about other biological pathways tha...

    Authors: Yunfeng Yang, Daniel P Harris, Feng Luo, Wenlu Xiong, Marcin Joachimiak, Liyou Wu, Paramvir Dehal, Janet Jacobsen, Zamin Yang, Anthony V Palumbo, Adam P Arkin and Jizhong Zhou
    Citation: BMC Genomics 2009 10:131
  16. Iron-deficiency anemia is the most prevalent form of anemia world-wide. The yeast Saccharomyces cerevisiae has been used as a model of cellular iron deficiency, in part because many of its cellular pathways are c...

    Authors: William J Jo, Jeung Hyoun Kim, Eric Oh, Daniel Jaramillo, Patricia Holman, Alex V Loguinov, Adam P Arkin, Corey Nislow, Guri Giaever and Chris D Vulpe
    Citation: BMC Genomics 2009 10:130
  17. The induction of genomic deletions by physical- or chemical- agents is an easy and inexpensive means to generate a genome-saturating collection of mutations. Different mutagens can be selected to ensure a muta...

    Authors: Myron Bruce, Ann Hess, Jianfa Bai, Ramil Mauleon, M Genaleen Diaz, Nobuko Sugiyama, Alicia Bordeos, Guo-Liang Wang, Hei Leung and Jan E Leach
    Citation: BMC Genomics 2009 10:129
  18. Although outer hair cells (OHCs) play a key role in cochlear amplification, it is not fully understood how they amplify sound signals by more than 100 fold. Two competing or possibly complementary mechanisms, ...

    Authors: Jing Zheng, Charles T Anderson, Katharine K Miller, MaryAnn Cheatham and Peter Dallos
    Citation: BMC Genomics 2009 10:127
  19. The balance between endothelial cell survival and apoptosis during stress is an important cellular process for vessel integrity and vascular homeostasis, and it is also pivotal in angiogenesis during the devel...

    Authors: Xingyi Hang, Peiyao Li, Zhifeng Li, Wubin Qu, Ying Yu, Hualing Li, Zhiyong Shen, Hao Zheng, Yan Gao, Yonghong Wu, Minghua Deng, Zhixian Sun and Chenggang Zhang
    Citation: BMC Genomics 2009 10:126
  20. A molecular process based genotype-to-phenotype map will ultimately enable us to predict how genetic variation among individuals results in phenotypic alterations. Building such a map is, however, far from str...

    Authors: Sergey V Nuzhdin, Jennifer A Brisson, Andrew Pickering, Marta L Wayne, Lawrence G Harshman and Lauren M McIntyre
    Citation: BMC Genomics 2009 10:124
  21. In bacteria, non-coding RNAs (ncRNA) are crucial regulators of gene expression, controlling various stress responses, virulence, and motility. Previous work revealed a relatively high number of ncRNAs in some ...

    Authors: Björn Voß, Jens Georg, Verena Schön, Susanne Ude and Wolfgang R Hess
    Citation: BMC Genomics 2009 10:123
  22. Correction to Bemmo A, Benovoy D, Kwan T, Gaffney DJ, Jensen RV, Majewski J: Gene expression and isoform variation analysis using Affymetrix Exon Arrays. BMC Genomics 2008, 9: 529.

    Authors: Amandine Bemmo, David Benovoy, Tony Kwan, Daniel J Gaffney, Roderick V Jensen and Jacek Majewski
    Citation: BMC Genomics 2009 10:121

    The original article was published in BMC Genomics 2008 9:529

  23. Sucrose content is a highly desirable trait in sugarcane as the worldwide demand for cost-effective biofuels surges. Sugarcane cultivars differ in their capacity to accumulate sucrose and breeding programs rou...

    Authors: Flávia S Papini-Terzi, Flávia R Rocha, Ricardo ZN Vêncio, Juliana M Felix, Diana S Branco, Alessandro J Waclawovsky, Luiz EV Del Bem, Carolina G Lembke, Maximiller DL Costa, Milton Y Nishiyama Jr, Renato Vicentini, Michel GA Vincentz, Eugênio C Ulian, Marcelo Menossi and Glaucia M Souza
    Citation: BMC Genomics 2009 10:120
  24. Mammal macrophages (MΦ) display a wide range of functions which contribute to surveying and maintaining tissue integrity. One such function is phagocytosis, a process known to be subverted by parasites like Leish...

    Authors: José Osorio y Fortéa, Emilie de La Llave, Béatrice Regnault, Jean-Yves Coppée, Geneviève Milon, Thierry Lang and Eric Prina
    Citation: BMC Genomics 2009 10:119
  25. Next-generation DNA sequencing on the 454, Solexa, and SOLiD platforms requires absolute calibration of the number of molecules to be sequenced. This requirement has two unfavorable consequences. First, large ...

    Authors: Richard A White III, Paul C Blainey, H Christina Fan and Stephen R Quake
    Citation: BMC Genomics 2009 10:116

    The Erratum to this article has been published in BMC Genomics 2009 10:541

  26. Proteolytic Clostridium botulinum is the causative agent of botulism, a severe neuroparalytic illness. Given the severity of botulism, surprisingly little is known of the population structure, biology, phylogeny ...

    Authors: Andrew T Carter, Catherine J Paul, David R Mason, Susan M Twine, Mark J Alston, Susan M Logan, John W Austin and Michael W Peck
    Citation: BMC Genomics 2009 10:115
  27. Nematoda diverged from other animals between 600–1,200 million years ago and has become one of the most diverse animal phyla on earth. Most nematodes are free-living animals, but many are parasites of plants a...

    Authors: Yong Yin, John Martin, Sahar Abubucker, Zhengyuan Wang, Lucjan Wyrwicz, Leszek Rychlewski, James P McCarter, Richard K Wilson and Makedonka Mitreva
    Citation: BMC Genomics 2009 10:114
  28. Angiogenesis correlates with patient survival following acute ischaemic stroke, and survival of neurons is greatest in tissue undergoing angiogenesis. Angiogenesis is critical for the development of new microv...

    Authors: Mark Slevin, Jerzy Krupinski, Norma Rovira, Marta Turu, Ana Luque, Maribel Baldellou, Coral Sanfeliu, Nuria de Vera and Lina Badimon
    Citation: BMC Genomics 2009 10:113
  29. A single Glycine max (soybean) genotype (Peking) reacts differently to two different populations of Heterodera glycines (soybean cyst nematode) within the first twelve hours of infection during resistant (R) and ...

    Authors: Vincent P Klink, Parsa Hosseini, Margaret H MacDonald, Nadim W Alkharouf and Benjamin F Matthews
    Citation: BMC Genomics 2009 10:111
  30. Dietary polyunsaturated fatty acids (PUFA), in particular the long chain marine fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA), are linked to many health benefits in humans and in animal models. ...

    Authors: Evert M van Schothorst, Pavel Flachs, Nicole LW Franssen-van Hal, Ondrej Kuda, Annelies Bunschoten, Jos Molthoff, Carolien Vink, Guido JEJ Hooiveld, Jan Kopecky and Jaap Keijer
    Citation: BMC Genomics 2009 10:110
  31. The pituitary is a critical neuroendocrine gland that is comprised of five hormone-secreting cell types, which develops in tandem during the embryonic stage. Some essential genes have been identified in the ea...

    Authors: Yueyun Ma, Xiaofei Qi, Jianjun Du, Shaojun Song, Dongyun Feng, Jia Qi, Zhidong Zhu, Xin Zhang, Huasheng Xiao, Zeguang Han and Xiaoke Hao
    Citation: BMC Genomics 2009 10:109
  32. Microscopic monogonont rotifers, including the euryhaline species Brachionus plicatilis, are typically found in water bodies where environmental factors restrict population growth to short periods lasting days or...

    Authors: Nadav Y Denekamp, Michael AS Thorne, Melody S Clark, Michael Kube, Richard Reinhardt and Esther Lubzens
    Citation: BMC Genomics 2009 10:108
  33. The apparent scarcity of available sequence data has greatly impeded evolutionary studies in Acari (mites and ticks). This subclass encompasses over 48,000 species and forms the largest group within the Arachn...

    Authors: Wannes Dermauw, Thomas Van Leeuwen, Bartel Vanholme and Luc Tirry
    Citation: BMC Genomics 2009 10:107
  34. The advent of high-throughput and cost-effective genotyping platforms made genome-wide association (GWA) studies a reality. While the primary focus has been invested upon the improvement of reducing genotyping...

    Authors: Wenqing Fu, Yi Wang, Ying Wang, Rui Li, Rong Lin and Li Jin
    Citation: BMC Genomics 2009 10:106
  35. Arsenic and cadmium are widely distributed in nature and pose serious threats to the environment and human health. Exposure to these nonessential toxic metals may result in a variety of human diseases includin...

    Authors: Michael Thorsen, Gabriel G Perrone, Erik Kristiansson, Mathew Traini, Tian Ye, Ian W Dawes, Olle Nerman and Markus J Tamás
    Citation: BMC Genomics 2009 10:105
  36. The availability of hundreds of bacterial genomes allowed a comparative genomic study of the Type VI Secretion System (T6SS), recently discovered as being involved in pathogenesis. By combining comparative and...

    Authors: Frédéric Boyer, Gwennaële Fichant, Jérémie Berthod, Yves Vandenbrouck and Ina Attree
    Citation: BMC Genomics 2009 10:104
  37. The anaerobic degradation of organic matter in natural environments, and the biotechnical use of anaerobes in energy production and remediation of subsurface environments, both require the cooperative activity...

    Authors: Jessica E Butler, Nelson D Young and Derek R Lovley
    Citation: BMC Genomics 2009 10:103
  38. The genus Actinidia (kiwifruit) consists of woody, scrambling vines, native to China, and only recently propagated as a commercial crop. All species described are dioecious, but the genetic mechanism for sex-dete...

    Authors: Lena G Fraser, Gianna K Tsang, Paul M Datson, H Nihal De Silva, Catherine F Harvey, Geoffrey P Gill, Ross N Crowhurst and Mark A McNeilage
    Citation: BMC Genomics 2009 10:102
  39. High throughput techniques have generated a huge set of biological data, which are deposited in various databases. Efficient exploitation of these databases is often hampered by a lack of appropriate tools, wh...

    Authors: Shizuka Uchida, André Schneider, Marion Wiesnet, Benno Jungblut, Polina Zarjitskaya, Katharina Jenniches, Karsten grosse Kreymborg, Werner Seeger and Thomas Braun
    Citation: BMC Genomics 2009 10:100
  40. Chromosomal rearrangements such as duplications and deletions are key factors in evolutionary processes because they promote genomic plasticity. Although the genetic variations in the Saccharomyces cerevisiae spe...

    Authors: Emilie S Fritsch, Joseph Schacherer, Claudine Bleykasten-Grosshans, Jean-Luc Souciet, Serge Potier and Jacky de Montigny
    Citation: BMC Genomics 2009 10:99
  41. Microarray expression profiling is becoming a routine technology for medical research and generates enormous amounts of data. However, reanalysis of public data and comparison with own results is laborious. Al...

    Authors: Adriane Menßen, Götz Edinger, Joachim R Grün, Ulrike Haase, Ria Baumgrass, Andreas Grützkau, Andreas Radbruch, Gerd-R Burmester and Thomas Häupl
    Citation: BMC Genomics 2009 10:98

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