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  1. Mosquito saliva, consisting of a mixture of dozens of proteins affecting vertebrate hemostasis and having sugar digestive and antimicrobial properties, helps both blood and sugar meal feeding. Culicine and ano...

    Authors: Eric Calvo, Van M Pham, Osvaldo Marinotti, John F Andersen and José MC Ribeiro
    Citation: BMC Genomics 2009 10:57
    Content type: Research article Published on:

  4. Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital ...

    Authors: Philip N Ward, Matthew TG Holden, James A Leigh, Nicola Lennard, Alexandra Bignell, Andy Barron, Louise Clark, Michael A Quail, John Woodward, Bart G Barrell, Sharon A Egan, Terence R Field, Duncan Maskell, Michael Kehoe, Christopher G Dowson, Neil Chanter…
    Citation: BMC Genomics 2009 10:54
    Content type: Research article Published on:

  5. Microorganisms adapt their transcriptome by integrating multiple chemical and physical signals from their environment. Shake-flask cultivation does not allow precise manipulation of individual culture paramete...

    Authors: Theo A Knijnenburg, Jean-Marc G Daran, Marcel A van den Broek, Pascale AS Daran-Lapujade, Johannes H de Winde, Jack T Pronk, Marcel JT Reinders and Lodewyk FA Wessels
    Citation: BMC Genomics 2009 10:53
    Content type: Research article Published on:

  6. Diapause is a reversible state of developmental suspension and found among diverse taxa, from plants to animals, including marsupials and some other mammals. Although previous work has accumulated ample data, ...

    Authors: Wie-Hua Chen, Xiaomeng Ge, Weiwei Wang, Jun Yu and Songnian Hu
    Citation: BMC Genomics 2009 10:52
    Content type: Research article Published on:

  7. Understanding structure and function of human genome requires knowledge of genomes of our closest living relatives, the primates. Nucleotide insertions and deletions (indels) play a significant role in differe...

    Authors: Natalia Volfovsky, Taras K Oleksyk, Kristine C Cruz, Ann L Truelove, Robert M Stephens and Michael W Smith
    Citation: BMC Genomics 2009 10:51
    Content type: Research article Published on:

  8. iTRAQ is a proteomics technique that uses isobaric tags for relative and absolute quantitation of tryptic peptides. In proteomics experiments, the detection and high confidence annotation of proteins and the s...

    Authors: Joost Lücker, Mario Laszczak, Derek Smith and Steven T Lund
    Citation: BMC Genomics 2009 10:50
    Content type: Research article Published on:

  9. High throughput methods, such as high density oligonucleotide microarray measurements of mRNA levels, are popular and critical to genome scale analysis and systems biology. However understanding the results of...

    Authors: Lecong Zhou, Santiago X Mideros, Lei Bao, Regina Hanlon, Felipe D Arredondo, Sucheta Tripathy, Konstantinos Krampis, Adam Jerauld, Clive Evans, Steven K St Martin, MA Saghai Maroof, Ina Hoeschele, Anne E Dorrance and Brett M Tyler
    Citation: BMC Genomics 2009 10:49
    Content type: Research article Published on:

  10. Α-gliadins form a multigene protein family encoded by multiple α-gliadin (Gli-2) genes at three genomic loci, Gli-A2, Gli-B2 and Gli-D2, respectively located on the homoeologous wheat chromosomes 6AS, 6BS, and 6D...

    Authors: Elma MJ Salentijn, Svetlana V Goryunova, Noor Bas, Ingrid M van der Meer, Hetty C van den Broeck, Thomas Bastien, Luud JWJ Gilissen and Marinus JM Smulders
    Citation: BMC Genomics 2009 10:48
    Content type: Research article Published on:

  12. In large genomics projects involving many different types of analyses of bacterial artificial chromosomes (BACs), such as fingerprinting, end sequencing (BES) and full BAC sequencing there are many opportuniti...

    Authors: Abhirami Ratnakumar, Wesley Barris, Sean McWilliam, Rudiger Brauning, John C McEwan, Warren M Snelling and Brian P Dalrymple
    Citation: BMC Genomics 2009 10:46
    Content type: Research article Published on:

  13. Most agriculturally important legumes fall within two sub-clades of the Papilionoid legumes: the Phaseoloids and Galegoids, which diverged about 50 Mya. The Phaseoloids are mostly tropical and include crops su...

    Authors: David J Bertioli, Marcio C Moretzsohn, Lene H Madsen, Niels Sandal, Soraya CM Leal-Bertioli, Patricia M Guimarães, Birgit K Hougaard, Jakob Fredslund, Leif Schauser, Anna M Nielsen, Shusei Sato, Satoshi Tabata, Steven B Cannon and Jens Stougaard
    Citation: BMC Genomics 2009 10:45
    Content type: Research article Published on:

  14. The filamentous fungus, Aspergillus niger, responds to nutrient availability by modulating secretion of various substrate degrading hydrolases. This ability has made it an important organism in industrial product...

    Authors: Thomas R Jørgensen, Theo Goosen, Cees AMJJ van den Hondel, Arthur FJ Ram and Jens JL Iversen
    Citation: BMC Genomics 2009 10:44
    Content type: Research article Published on:

  15. Recent segmental duplications are relatively large (≥ 1 kb) genomic regions of high sequence identity (≥ 90%). They cover approximately 4–5% of the human genome and play important roles in gene evolution and g...

    Authors: Sigve Nakken, Einar A Rødland, Torbjørn Rognes and Eivind Hovig
    Citation: BMC Genomics 2009 10:43
    Content type: Research article Published on:

  17. Wood is a major renewable natural resource for the timber, fibre and bioenergy industry. Pinus radiata D. Don is the most important commercial plantation tree species in Australia and several other countries; how...

    Authors: Xinguo Li, Harry X Wu, Shannon K Dillon and Simon G Southerton
    Citation: BMC Genomics 2009 10:41
    Content type: Research article Published on:

  18. The native Australian fly Drosophila serrata belongs to the highly speciose montium subgroup of the melanogaster species group. It has recently emerged as an excellent model system with which to address a number ...

    Authors: Francesca D Frentiu, Marcin Adamski, Elizabeth A McGraw, Mark W Blows and Stephen F Chenoweth
    Citation: BMC Genomics 2009 10:40
    Content type: Research article Published on:

  19. Genomic discovery in oat and its application to oat improvement have been hindered by a lack of genetic markers common to different genetic maps, and by the difficulty of conducting whole-genome analysis using...

    Authors: Nicholas A Tinker, Andrzej Kilian, Charlene P Wight, Katarzyna Heller-Uszynska, Peter Wenzl, Howard W Rines, Ã…smund Bjørnstad, Catherine J Howarth, Jean-Luc Jannink, Joseph M Anderson, Brian G Rossnagel, Deon D Stuthman, Mark E Sorrells, Eric W Jackson, Stine Tuvesson, Frederic L Kolb…
    Citation: BMC Genomics 2009 10:39
    Content type: Research article Published on:

  20. High throughput proteomics experiments are useful for analyzing the protein expression of an organism, identifying the correct gene structure of a genome, or locating possible post-translational modifications ...

    Authors: Carlos J Madrid-Aliste, Joseph M Dybas, Ruth Hogue Angeletti, Louis M Weiss, Kami Kim, Istvan Simon and Andras Fiser
    Citation: BMC Genomics 2009 10:38
    Content type: Database Published on:

  21. Short-read high-throughput DNA sequencing technologies provide new tools to answer biological questions. However, high cost and low throughput limit their widespread use, particularly in organisms with smaller...

    Authors: Philippe Lefrançois, Ghia M Euskirchen, Raymond K Auerbach, Joel Rozowsky, Theodore Gibson, Christopher M Yellman, Mark Gerstein and Michael Snyder
    Citation: BMC Genomics 2009 10:37
    Content type: Methodology article Published on:

  22. Of the > 2000 serovars of Salmonella enterica subspecies I, most cause self-limiting gastrointestinal disease in a wide range of mammalian hosts. However, S. enterica serovars Typhi and Paratyphi A are restricted...

    Authors: Kathryn E Holt, Nicholas R Thomson, John Wain, Gemma C Langridge, Rumina Hasan, Zulfiqar A Bhutta, Michael A Quail, Halina Norbertczak, Danielle Walker, Mark Simmonds, Brian White, Nathalie Bason, Karen Mungall, Gordon Dougan and Julian Parkhill
    Citation: BMC Genomics 2009 10:36
    Content type: Research article Published on:

  23. Mast cells (MCs) play pivotal roles in allergy and innate immunity and consist of heterogenous subclasses. However, the molecular basis determining the different characteristics of these multiple MC subclasses...

    Authors: Soken Tsuchiya, Yuki Tachida, Eri Segi-Nishida, Yasushi Okuno, Shigero Tamba, Gozoh Tsujimoto, Satoshi Tanaka and Yukihiko Sugimoto
    Citation: BMC Genomics 2009 10:35
    Content type: Research article Published on:

  24. Zymomonas mobilis ZM4 (ZM4) produces near theoretical yields of ethanol with high specific productivity and recombinant strains are able to ferment both C-5 and C-6 sugars. Z. mobilis performs best under anaerobi...

    Authors: Shihui Yang, Timothy J Tschaplinski, Nancy L Engle, Sue L Carroll, Stanton L Martin, Brian H Davison, Anthony V Palumbo, Miguel Rodriguez Jr and Steven D Brown
    Citation: BMC Genomics 2009 10:34
    Content type: Research article Published on:

  25. The evolutionary importance of horizontal gene transfer (HGT) from Wolbachia endosymbiotic bacteria to their eukaryotic hosts is a topic of considerable interest and debate. Recent transfers of genome fragments f...

    Authors: Lisa Klasson, Zakaria Kambris, Peter E Cook, Thomas Walker and Steven P Sinkins
    Citation: BMC Genomics 2009 10:33
    Content type: Research article Published on:

  26. Genomic analysis will greatly benefit from considering in a global way various sources of molecular data with the related biological knowledge. It is thus of great importance to provide useful integrative appr...

    Authors: Marie de Tayrac, Sébastien Lê, Marc Aubry, Jean Mosser and François Husson
    Citation: BMC Genomics 2009 10:32
    Content type: Methodology article Published on:

  27. Avian coccidiosis is a major parasitic disease of poultry, causing severe economical loss to poultry production by affecting growth and feed efficiency of infected birds. Current control strategies using mainl...

    Authors: Marie-Hélène Pinard-van der Laan, Bertrand Bed'hom, Jean-Luc Coville, Frédérique Pitel, Katia Feve, Sophie Leroux, Hélène Legros, Aurélie Thomas, David Gourichon, Jean-Michel Repérant and Paul Rault
    Citation: BMC Genomics 2009 10:31
    Content type: Research article Published on:

  28. The recent development within high-throughput technologies for expression profiling has allowed for parallel analysis of transcriptomes and proteomes in biological systems such as comparative analysis of trans...

    Authors: Henrik Hornshøj, Emøke Bendixen, Lene N Conley, Pernille K Andersen, Jakob Hedegaard, Frank Panitz and Christian Bendixen
    Citation: BMC Genomics 2009 10:30
    Content type: Research article Published on:

  29. Whole genome sequencing techniques have added a new dimension to studies on bacterial adaptation, evolution and diversity in chronic infections. By using this powerful approach it was demonstrated that Pseudomona...

    Authors: Andreas Dötsch, Claudia Pommerenke, Florian Bredenbruch, Robert Geffers and Susanne Häussler
    Citation: BMC Genomics 2009 10:29
    Content type: Methodology article Published on:

  30. Current techniques of screening bacterial artificial chromosome (BAC) libraries for molecular markers during the construction of physical maps are slow, laborious and often assign multiple BAC contigs to a sin...

    Authors: Ming-Cheng Luo, Kenong Xu, Yaqin Ma, Karin R Deal, Charles M Nicolet and Jan Dvorak
    Citation: BMC Genomics 2009 10:28
    Content type: Methodology article Published on:

  31. Mitochondrial genomes are a valuable source of data for analysing phylogenetic relationships. Besides sequence information, mitochondrial gene order may add phylogenetically useful information, too. Sipuncula ...

    Authors: Adina Mwinyi, Achim Meyer, Christoph Bleidorn, Bernhard Lieb, Thomas Bartolomaeus and Lars Podsiadlowski
    Citation: BMC Genomics 2009 10:27
    Content type: Research article Published on:

  32. Analyzing gene expression data by assessing the significance of pre-defined gene sets, rather than individual genes, has become a main approach in microarray data analysis and this has promisingly derive new b...

    Authors: Chien-Yi Tung, Chih-Hung Jen, Ming-Ta Hsu, Hsei-Wei Wang and Chi-Hung Lin
    Citation: BMC Genomics 2009 10:26
    Content type: Methodology article Published on:

  33. Infection of cattle with Mycobacterium avium subspecies paratuberculosis (M. ap) causes severe economic losses to the dairy industry in the USA and worldwide. In an effort to better examine diversity among M. ap ...

    Authors: Chia-wei Wu, Timothy M Schramm, Shiguo Zhou, David C Schwartz and Adel M Talaat
    Citation: BMC Genomics 2009 10:25
    Content type: Research article Published on:

  34. The dog is an important model organism and it is considered to be closer to humans than rodents regarding metabolism and responses to drugs. The close relationship between humans and dogs over many centuries h...

    Authors: Tatjana Haitina, Robert Fredriksson, Steven M Foord, Helgi B Schiöth and David E Gloriam
    Citation: BMC Genomics 2009 10:24
    Content type: Research article Published on:

  36. Biologists need to perform complex queries, often across a variety of databases. Typically, each data resource provides an advanced query interface, each of which must be learnt by the biologist before they ca...

    Authors: Damian Smedley, Syed Haider, Benoit Ballester, Richard Holland, Darin London, Gudmundur Thorisson and Arek Kasprzyk
    Citation: BMC Genomics 2009 10:22
    Content type: Software Published on:

  37. Evolution has resulted in large repertoires of olfactory receptor (OR) genes, forming the largest gene families in mammalian genomes. Knowledge of the genetic diversity of olfactory receptors is essential if w...

    Authors: Stéphanie Robin, Sandrine Tacher, Maud Rimbault, Amaury Vaysse, Stéphane Dréano, Catherine André, Christophe Hitte and Francis Galibert
    Citation: BMC Genomics 2009 10:21
    Content type: Research article Published on:

  38. Marek's disease (MD) is a T-cell lymphoma of chickens caused by the Marek's disease virus (MDV), an oncogenic avian herpesvirus. MD is a major cause of economic loss to the poultry industry and the most seriou...

    Authors: Eliyahu M Heifetz, Janet E Fulton, Neil P O'Sullivan, James A Arthur, Hans Cheng, Jing Wang, Morris Soller and Jack CM Dekkers
    Citation: BMC Genomics 2009 10:20
    Content type: Research article Published on:

  39. The basis of genome size variation remains an outstanding question because DNA sequence data are lacking for organisms with large genomes. Sixteen BAC clones from the Mexican axolotl (Ambystoma mexicanum: c-value...

    Authors: Jeramiah J Smith, Srikrishna Putta, Wei Zhu, Gerald M Pao, Inder M Verma, Tony Hunter, Susan V Bryant, David M Gardiner, Timothy T Harkins and S Randal Voss
    Citation: BMC Genomics 2009 10:19
    Content type: Research article Published on:

  40. Regulation of gene expression in Plasmodium falciparum (Pf) remains poorly understood. While over half the genes are estimated to be regulated at the transcriptional level, few regulatory motifs and transcription...

    Authors: Prathima Iengar and NV Joshi
    Citation: BMC Genomics 2009 10:18
    Content type: Research article Published on:

  41. Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of th...

    Authors: Toshiaki Matsui, Toshiyuki Yamamoto, Stefan Wyder, Evgeny M Zdobnov and Tatsuhiko Kadowaki
    Citation: BMC Genomics 2009 10:17
    Content type: Research article Published on:

  42. With the recent completion of numerous sequenced bacterial genomes, notable advances have been made in understanding the level of conservation between various species. However, relatively little is known about...

    Authors: Michael J Dark, David R Herndon, Lowell S Kappmeyer, Mikel P Gonzales, Elizabeth Nordeen, Guy H Palmer, Donald P Knowles Jr and Kelly A Brayton
    Citation: BMC Genomics 2009 10:16
    Content type: Research article Published on:

  43. The nucleosome is the fundamental unit of eukaryotic genomes. Its positioning plays a central role in diverse cellular processes that rely on access to genomic DNA. Experimental evidence suggests that the geno...

    Authors: Zhiming Dai, Xianhua Dai, Qian Xiang, Jihua Feng, Jiang Wang, Yangyang Deng and Caisheng He
    Citation: BMC Genomics 2009 10:15
    Content type: Research article Published on:

  45. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries most frequently than any other body vessel. There may be common molecular pathways sustaining this process. Plaque presence and diffusion is...

    Authors: Stefano Cagnin, Michele Biscuola, Cristina Patuzzo, Elisabetta Trabetti, Alessandra Pasquali, Paolo Laveder, Giuseppe Faggian, Mauro Iafrancesco, Alessandro Mazzucco, Pier Franco Pignatti and Gerolamo Lanfranchi
    Citation: BMC Genomics 2009 10:13
    Content type: Research article Published on:

  46. Plasmids are extrachromosomal elements that replicate autonomously, and many can be transmitted between bacterial cells through conjugation. Although the transcription pattern of genes on a plasmid can be alte...

    Authors: Masatoshi Miyakoshi, Hiromi Nishida, Masaki Shintani, Hisakazu Yamane and Hideaki Nojiri
    Citation: BMC Genomics 2009 10:12
    Content type: Research article Published on:

  47. Cold adapted or psychrophilic organisms grow at low temperatures, where most of other organisms cannot grow. This adaptation requires a vast array of sequence, structural and physiological adjustments. To unde...

    Authors: Raghu Prasad Rao Metpally and Boojala Vijay B Reddy
    Citation: BMC Genomics 2009 10:11
    Content type: Research article Published on:

  48. The first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have far reaching implication for in vitro...

    Authors: Said Assou, Doris Cerecedo, Sylvie Tondeur, Véronique Pantesco, Outi Hovatta, Bernard Klein, Samir Hamamah and John De Vos
    Citation: BMC Genomics 2009 10:10
    Content type: Research article Published on:

  49. Transcriptional regulatory elements are central to development and interspecific phenotypic variation. Current regulatory element prediction tools rely heavily upon conservation for prediction of putative elem...

    Authors: David M McGaughey, Zachary E Stine, Jimmy L Huynh, Ryan M Vinton and Andrew S McCallion
    Citation: BMC Genomics 2009 10:8
    Content type: Research article Published on:

  50. Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient. Although an understanding of the heme acquisition mechanisms of H. influenzae is emergi...

    Authors: Paul W Whitby, Thomas W Seale, Timothy M VanWagoner, Daniel J Morton and Terrence L Stull
    Citation: BMC Genomics 2009 10:6
    Content type: Research article Published on:

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